Issue: March 2021

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HLA Fuels Autoimmunity, HLA Testing Fuels Treatment
Many of us have had the sensation of passing by a random mirror in a public place and wondering, who is that? Do I really look like that? Or, more often, I don’t look like that in my mirror at home. Who is that person who looks too ruddy/hefty/wrinkled, or really too old to be me? Our immune systems sometimes face the same dilemma. They can recognize viruses and bacteria that cause illness, and destroy them. But sometimes our system does not recognize what it sees. “What is that?” it might ask. “Is that really me, or is that a vicious virus?”

Longitudinal Sampling for a Lifelong Disease: Systemic Lupus Erythematosus
As a chronic autoimmune disease, patients with systemic lupus erythematosus (SLE) experience widespread inflammation and unpredictable disease flare episodes that progressively worsen over time, contributing to tissue and organ damage. Its heterogeneous nature, slow disease progression, and seemingly random symptom flares complicate research studies aimed at improving therapeutic options for SLE patients.

Precision Medicine for Genetic Disease: from Prevention to Treatment
Jun Liao, Ph.D., FACMG, Laboratory Director and Assistant Professor @Columbia University Medical Center
Contemporary Concepts in Autoimmune Disease Research
PANEL: Building Bridges From Bedside to Bench and Back

Sanguine in the news
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses
Bruce, Bracken, Evans et al
PLoS pathogens (2021)

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases
Tarke, Sidney, Kidd et al
Cell reports. Medicine

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