Chicken-or-Egg Paradox Sheds
Light on Genetic Variants
The dilemma of untangling cause and effect is perhaps best encapsulated by the chicken-or-egg paradox. It may provide cocktail party banter, but to an evolutionary biologist, it’s pretty simple: eggs are much older than chickens. At some point, an almost-complete chicken creature produced an egg from which a full-fledged chick pecked its way out.
Circulating Tumor Cells and
Indicators in Cancer
Circulating tumor cells (CTCs) are cancer cells that have detached from the primary tumor and can be detected in a patient’s blood. These cells are what drives metastasis–when some of these cells move out of the bloodstream, they act like seeds to establish secondary tumors in other parts of the body. Less than 0.1% of CTCs actually go on to form metastatic tumors, but they are the primary cause for cancer resurgence following remission and cancer-related deaths.
Longitudinal assessment of
adhesion to vascular cell adhesion
molecule-1 at steady state and
during vaso-occlusive crises in
sickle cell disease
White, Callaghan, Gao et al
Br J Haematol
Flow adhesion of whole blood to
P-selectin: a prognostic biomarker
for vaso-occlusive crisis in sickle
cell disease
Hines, Callaghan, Zaidi et al
Br J Haematol (2021)
