Myalgic Encephalomyelitis PBMC
About: Myalgic Encephalomyelitis PBMC samples are isolated from donors with clinically diagnosed myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Ideal for studying immune dysfunction, chronic inflammation, and abnormalities in T cell and NK cell function associated with persistent fatigue and post-exertional malaise.
Myalgic Encephalomyelitis PBMC for Research
Myalgic Encephalomyelitis PBMC samples are collected from donors clinically diagnosed with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) and processed under controlled conditions to support neuroimmunology research. These cryopreserved peripheral blood mononuclear cells (PBMCs) enable studies of immune dysfunction, chronic inflammation, and NK- and T-cell abnormalities associated with persistent fatigue and post-exertional malaise.
Product Features
- Research Use Only (RUO), cryopreserved ME/CFS PBMC samples
- Clinically confirmed ME/CFS donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Preserved using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screening (LeukoLot™) available prior to bulk orders
De-identified Donor Data
- Verified ME/CFS diagnosis
- Donor demographics: age, sex assigned at birth, race/ethnicity
- Self-reported allergies and infectious disease history
- Additional ME/CFS-specific clinical data available on request
Applications
- Biomarker discovery and validation
- Immune-pathway and NK/T-cell analysis in ME/CFS
- Drug screening and therapeutic development
- Transcriptomic and proteomic profiling
Quality and Compliance
- IRB-approved collections and protocols
- 21 CFR Part 11-compliant e-consent
- HIPAA-compliant donor data protection
Ordering & Shipping
Myalgic Encephalomyelitis PBMC samples ship on dry ice in standard or custom aliquots. For international orders or regulatory documentation, contact learnmore@sanguinebio.com. Browse all human PBMCs or request a custom disease-state collection.
Protocols & Documentation
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PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
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Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
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Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Frequently Asked Questions
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Electronic medical records are an option to be included with the PBMC sample, as well as, flow cytometry and other phenotypic testing.
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YES – we can often accommodate treatment-naive samples including various cancers, and you can specify immunosupression status or other requirements in the I/E criteria.
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Self-reported infectious disease testing is always available and some of our products have additional testing.
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HLA-typing is available for some of our PBMC products.
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YES to both – Unique donors can be specified, and multiple vials from the same donor can be arranged. You can specify these requirements when ordering.
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Healthy PBMCs achieve over 90% vialbity post-thaw. Although our disease-state PBMCs are processed with same stringent SOP, there is more variability depending upon disease. Learn more about our post thaw viability here. https://sanguinebio.com/pbmc-viability-quality-assurance/
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Need a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.