Myotonic Dystrophy PBMC
About: Myotonic Dystrophy PBMC samples are isolated from donors with genetically confirmed Myotonic Dystrophy (DM). Ideal for studying RNA splicing abnormalities, immune dysregulation, and multisystemic involvement in this progressive neuromuscular disorder.
Myotonic Dystrophy PBMC for Research
Myotonic Dystrophy PBMC samples are collected from donors clinically or genetically diagnosed with myotonic dystrophy and processed under controlled conditions to support neuromuscular and rare-disease research. These cryopreserved peripheral blood mononuclear cells (PBMCs) enable studies of immune dysregulation and multisystemic involvement in this progressive neuromuscular disorder.
Product Features
- Research Use Only (RUO), cryopreserved myotonic dystrophy PBMC samples
- Clinically confirmed myotonic dystrophy donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Preserved using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screening (LeukoLot™) available prior to bulk orders
De-identified Donor Data
- Verified myotonic dystrophy diagnosis
- Donor demographics: age, sex assigned at birth, race/ethnicity
- Self-reported allergies and infectious disease history
- Additional myotonic dystrophy-specific clinical data available on request
Applications
- Biomarker discovery and validation
- Immune-pathway analysis in myotonic dystrophy
- Drug screening and therapeutic development
- Transcriptomic and proteomic profiling
Quality and Compliance
- IRB-approved collections and protocols
- 21 CFR Part 11-compliant e-consent
- HIPAA-compliant donor data protection
Ordering & Shipping
Myotonic Dystrophy PBMC samples ship on dry ice in standard or custom aliquots. For international orders or regulatory documentation, contact learnmore@sanguinebio.com. Browse all human PBMCs or request a custom disease-state collection.
Protocols & Documentation
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PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
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Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
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Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Frequently Asked Questions
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Electronic medical records are an option to be included with the PBMC sample, as well as, flow cytometry and other phenotypic testing.
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YES – we can often accommodate treatment-naive samples including various cancers, and you can specify immunosupression status or other requirements in the I/E criteria.
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Self-reported infectious disease testing is always available and some of our products have additional testing.
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HLA-typing is available for some of our PBMC products.
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YES to both – Unique donors can be specified, and multiple vials from the same donor can be arranged. You can specify these requirements when ordering.
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Healthy PBMCs achieve over 90% vialbity post-thaw. Although our disease-state PBMCs are processed with same stringent SOP, there is more variability depending upon disease. Learn more about our post thaw viability here. https://sanguinebio.com/pbmc-viability-quality-assurance/
Ask a Question
Need a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.