Secondary Progressive Multiple Sclerosis PBMC
About: Secondary Progressive Multiple Sclerosis PBMC samples are collected from clinically confirmed secondary progressive multiple sclerosis (SPMS) donors and cryopreserved for downstream immunology and biomarker detection studies. Ideal for studying inflammatory pathways, immune cell responses, and therapeutic development in SPMS.
High-Quality Secondary Progressive Multiple Sclerosis PBMC for Research
Secondary Progressive Multiple Sclerosis PBMC products are sourced from donors clinically diagnosed with secondary progressive multiple sclerosis (SPMS) and processed under stringent conditions to support immune response in oncology research. These cryopreserved peripheral blood mononuclear cells (PBMCs) enable studies on immune response and biomarker identification.
Product Features
- Research Use Only (RUO), cryopreserved SPMS PBMC Samples
- Clinically confirmed SPMS donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Stored using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screen LeukoLot™ available prior to bulk orders
De-identified Donor Data
- Verified SPMS diagnosis
- Donor demographics: age, sex assigned at birth, race/ethnicity
- Self-reported allergies and infectious disease history
- Additional SPMS-specific data available upon request
Applications
- Biomarker discovery and validation
- Drug screening and therapeutic development
- Immune pathway analysis in SPMS pathophysiology
- Transcriptomic and proteomic profiling
Quality and Compliance
- IRB-approved collections and protocols
- 21 CFR Part 11 – compliant e-consent system
- HIPAA-compliant donor data protection
Ordering & Shipping
Secondary Progressive Multiple Sclerosis PBMC samples are shipped on dry ice and available in custom aliquots. For international orders or regulatory requirements, please contact learnmore@sanguinebio.com to confirm documentation and compliance needs.
Protocols & Documentation
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PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
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Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
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Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Frequently Asked Questions
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Electronic medical records are an option to be included with the PBMC sample, as well as, flow cytometry and other phenotypic testing.
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YES – we can often accommodate treatment-naive samples including various cancers, and you can specify immunosupression status or other requirements in the I/E criteria.
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Self-reported infectious disease testing is always available and some of our products have additional testing.
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HLA-typing is available for some of our PBMC products.
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YES to both – Unique donors can be specified, and multiple vials from the same donor can be arranged. You can specify these requirements when ordering.
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Healthy PBMCs achieve over 90% vialbity post-thaw. Although our disease-state PBMCs are processed with same stringent SOP, there is more variability depending upon disease. Learn more about our post thaw viability here. https://sanguinebio.com/pbmc-viability-quality-assurance/
Ask a Question
Need a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.