Wilson’s Disease PBMC
About: Wilson’s Disease PBMC samples are isolated from donors with genetically confirmed Wilson’s Disease (WD). Ideal for studying copper metabolism disorders, immune responses to hepatic injury, and gene-environment interactions in WD.
Wilson’s Disease PBMC for Research
Wilson’s Disease PBMC samples are collected from donors clinically diagnosed with Wilson’s disease (ATP7B copper-transport deficiency) and processed under controlled conditions to support immunology and rare-disease research. These cryopreserved peripheral blood mononuclear cells (PBMCs) support studies of immune responses to copper-driven hepatic injury, inflammatory signaling, and biomarker discovery in Wilson’s disease.
Product Features
- Research Use Only (RUO), cryopreserved Wilson’s disease PBMC samples
- Clinically confirmed Wilson’s disease donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Preserved using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screening (LeukoLot™) available prior to bulk orders
De-identified Donor Data
- Verified Wilson’s disease diagnosis
- Donor demographics: age, sex assigned at birth, race/ethnicity
- Self-reported allergies and infectious disease history
- Additional Wilson’s disease-specific clinical data available on request
Applications
- Biomarker discovery and validation
- Immune-pathway analysis in Wilson’s disease
- Drug screening and therapeutic development
- Transcriptomic and proteomic profiling
Quality and Compliance
- IRB-approved collections and protocols
- 21 CFR Part 11-compliant e-consent
- HIPAA-compliant donor data protection
Ordering & Shipping
Wilson’s Disease PBMC samples ship on dry ice in standard or custom aliquots. For international orders or regulatory documentation, contact learnmore@sanguinebio.com. Browse all human PBMCs or request a custom disease-state collection.
Protocols & Documentation
-
Download
PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
-
Download
Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
-
Download
Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
-
Download
Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
-
Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Frequently Asked Questions
1 Answer
Electronic medical records are an option to be included with the PBMC sample, as well as, flow cytometry and other phenotypic testing.
1 Answer
YES – we can often accommodate treatment-naive samples including various cancers, and you can specify immunosupression status or other requirements in the I/E criteria.
1 Answer
Self-reported infectious disease testing is always available and some of our products have additional testing.
1 Answer
HLA-typing is available for some of our PBMC products.
1 Answer
YES to both – Unique donors can be specified, and multiple vials from the same donor can be arranged. You can specify these requirements when ordering.
1 Answer
Healthy PBMCs achieve over 90% vialbity post-thaw. Although our disease-state PBMCs are processed with same stringent SOP, there is more variability depending upon disease. Learn more about our post thaw viability here. https://sanguinebio.com/pbmc-viability-quality-assurance/
Ask a Question
Need a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.