PBMC

High-Quality PBMCs for Research

Human PBMCs are sourced from healthy and disease-state donors and processed under controlled conditions to support high-quality research. These cryopreserved peripheral blood mononuclear cells enable studies in immune function, cytokine response, biomarker discovery, cell therapy research, and therapeutic screening.

Whether you need PBMCs as matched controls, disease-state comparators, or custom donor-defined samples, Sanguine helps research teams source PBMCs aligned to protocol requirements and downstream assay needs.

What Is a PBMC?

A peripheral blood mononuclear cell (PBMC) is any blood cell with a round nucleus — including lymphocytes (T cells, B cells, and NK cells), monocytes, and dendritic cells. PBMCs are isolated from whole blood or a leukopak by density-gradient separation, which removes red blood cells and granulocytes. Because they contain the key effector cells of the immune system, human PBMCs are one of the most widely used starting materials in immunology, immuno-oncology, and cell and gene therapy research.

Product Features

• Research use only cryopreserved human PBMCs
• Sourced from healthy and disease-state donors
• Available in cell counts ranging from 5 million to 2 billion
• Processed within 24 hours of collection
• Preserved using CryoStor CS10 freezing media
• Designed to support cell viability and functional assays
• IRB-approved protocols and electronic informed consent
• Screening and bulk-order support available for larger PBMC programs

De-identified Donor Data

Available donor-level information helps researchers select PBMC samples that align to study design and population requirements.

• Donor demographics including age, sex assigned at birth, and race/ethnicity
• Self-reported allergies and infectious disease history
• Healthy donor and disease-state context where applicable
• Additional donor-specific data available upon request
• Study-specific donor requirements may be supported for custom programs

Applications

Human PBMCs support a broad range of immunology and translational research workflows.

• Biomarker discovery and validation
• Drug screening and therapeutic development
• Immune pathway analysis
• Cytokine and functional immune assays
• Transcriptomic and proteomic profiling
• Cell-based assay development
• Matched control and disease-state comparison studies

Disease-State PBMC Samples

Sanguine offers PBMCs from donors with confirmed diagnoses across a range of conditions, including:

• Systemic Sclerosis PBMC
• Interstitial Lung Disease PBMC
• Anemia PBMC
• Acromegaly PBMC
• Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) PBMC
• MPS II Hunter Syndrome PBMC
• Warm Antibody Autoimmune Hemolytic Anemia (wAIHA) PBMC
• Type 2 Diabetes (T2D) PBMC

For related products, see our human leukopak and human whole blood.

Quality and Compliance

• IRB-approved collections and protocols
• 21 CFR Part 11-compliant electronic informed consent
• HIPAA-compliant donor data protection
• Controlled processing workflows designed to support PBMC quality
• Documentation available for qualified research programs

Ordering & Shipping

Human PBMC samples are shipped on dry ice and are available in multiple cryopreserved configurations to support a range of research needs. If your project requires custom aliquots, larger bulk orders, or international documentation, our team can help identify the right fulfillment path. For international orders or regulatory requirements, please contact learnmore@sanguinebio.com.

Buy Human PBMCs for Research

Sanguine is a trusted supplier of human PBMCs for research, offering healthy and disease-state PBMC samples from a community of 70,000+ donors. Purchase fresh or cryopreserved patient PBMCs with full donor data, or commission a custom PBMC collection built to your inclusion/exclusion criteria. Browse in-stock PBMC samples above or request a quote to buy PBMCs for your study.

Frequently Asked Questions About Buying PBMCs

How do I buy PBMCs for research?

Browse the in-stock human PBMC samples above or request a quote. Sanguine supplies fresh and cryopreserved PBMCs from healthy and disease-state donors, with custom collections available to your study criteria.

Do you offer disease-state and patient PBMCs?

Yes. We provide disease-state and patient PBMC samples across 100+ confirmed conditions, plus healthy controls — see the disease-state PBMC list above or request a custom cohort.

Are PBMC samples available for sale fresh and cryopreserved?

Yes. Human PBMC samples are available for purchase in both fresh and cryopreserved formats, in cell counts ranging from 5 million to 2 billion per vial.