Translational research emerged as the missing link between basic science and advances in clinical practice meant to markedly improve individual and public health. Knowledge acquired from basic science doesn’t automatically improve public health, and the lack of intentionality in fostering translation of scientific discoveries contributed to the “valley of death” in research – a gap characterized by the failure to connect the bench to the bedside. Other factors such as misconceptions, miscommunication, and research studies that lack clinical relevance also add to the problem.
Despite all the scientific progress made to date, an estimated 95% of human diseases have no treatment, a number that highlights the urgency of the matter. According to the National Center for Advancing Translational Science, “translation is the process of turning observation in the laboratory, clinic, and community into interventions that improve the health of individuals and the public – from diagnostics and therapeutics to medical procedures and behavioral changes.” Stakeholders involved in the process of research translation need to work together to close the gap by increasing collaboration, improving communication, and taking advantage of improvements in the field of biomarkers to promote precision medicine. Overcoming the valley of death will require change, and Sanguine Biosciences is at the forefront of promoting an innovative approach that directly addresses the challenges in translational research. Our goal is to catalyze translation by bridging the gap between investigators and patients.