Infectious Disease Biospecimens
Infectious Disease Biospecimens: Accelerate breakthrough research in viral infections with premium-quality specimens, comprehensive genomic annotation, and ethically sourced bio samples from donors with confirmed COVID-19, HIV, Hepatitis B, Hepatitis C, HPV, and Cytomegalovirus (CMV).
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Access a Comprehensive Portfolio of Infectious Disease Biospecimens
Our extensive donor network across the United States supports cutting-edge research into major viral infections including COVID-19 (SARS-CoV-2), HIV/AIDS, Hepatitis B and C, Human Papillomavirus (HPV), and Cytomegalovirus (CMV). Whether you need cross-sectional or longitudinal collections, matched sample sets, or custom cohorts tailored to your protocol, we provide the precise specimens and deep clinical annotation required for impactful infectious disease research. From study design to receipt of samples, our team ensures your research timeline stays on track while maintaining the highest quality standards.
Infectious diseases continue to pose significant global health challenges, affecting millions of people annually and driving substantial morbidity and mortality worldwide.1,2 The COVID-19 pandemic underscored the critical importance of rapid access to well-characterized biospecimens for vaccine development, therapeutic validation, and biomarker discovery.3 Similarly, persistent viral infections such as HIV, hepatitis viruses, and HPV require robust specimen resources to advance precision medicine approaches and develop next-generation diagnostics and treatments.4,5
Why Choose Sanguine for Infectious Disease Specimen Solutions
Infectious disease research demands high-quality biospecimens, rigorous clinical annotation, and compliance with ethical and regulatory standards. Our direct-to-patient model and comprehensive services deliver exactly what your research requires.
Direct-to-Patient Model & Engaged Network
Our network across the United States provides access to well-characterized donors with confirmed infectious diseases, streamlining procurement from study design to receipt of samples so you can focus on discovery
Custom collection services
If what you need isn't available in our inventory, we will recruit and collect from a custom cohort tailored to your specific inclusion/exclusion criteria, disease stage, treatment status, and timeline requirements.
Access to Hard-to-Find Populations
Acute vs. chronic infections, treatment-naïve vs. treatment-experienced, co-infected populations, specific viral strains or variant —we work with you to source the right patients for your research objectives.
Matched Sample Sets & Multiomics-Ready Specimens
Obtain multiple sample types from the same donor—whole blood, plasma, serum, PBMCs, urine—enabling holistic biomarker analysis across matrices. All specimens can be paired with genetic testing data, enzyme activity assays, and clinical phenotyping for multi-omic integration
Comprehensive Clinical & Molecular Annotation
Receive samples paired with rich patient data which may include—donor demographics, confirmed infection status, natural history, treatment regimens, viral load measurements, co-morbidities, and outcomes data. Where available, specimens include molecular profiling such as viral genotyping, host genomic data, and biomarker levels. 6,7
Ethical Sourcing & Regulatory Compliance
Our processes meet rigorous ethical and data-security standards (ISO certifications, HIPAA compliance, data privacy protection) which gives you confidence in your research tools and regulatory submissions.
Infectious Disease Specimen Portfolio
Available Specimen Types Include:
Plasma & Serum
High-quality plasma and serum specimens collected with standardized protocols for viral load quantification, antibody profiling, cytokine analysis, and biomarker discovery studies.
Format Options: Frozen aliquots, EDTA plasma, heparin plasma, or custom anticoagulants
Whole Blood & PBMCs
Whole blood specimens and isolated peripheral blood mononuclear cells enabling immune phenotyping, T-cell and B-cell analysis, viral reservoir studies, and host response characterization.
Format Options: EDTA, heparin, or custom anticoagulants for whole blood; cryopreserved PBMCs with documented viability
Saliva, Urine & Stool Specimens
Non-invasive specimen types ideal for viral shedding studies, microbiome research, diagnostic development, and population screening applications.
Specialized Collections
Longitudinal (serial) collections to track natural history, treatment response, immune dynamics, and viral evolution over time
Rich Clinical and Molecular Annotation
Many of our infectious disease biospecimens come with detailed patient documentation, enabling them to function as true translational research tools.
Demographics & clinical characteristics
Confirmed infection status, age at diagnosis, gender, race/ethnicity, co-morbidities, co infection status, geographic region, transmission category (where applicable)
Treatment history
Antiviral therapies (dosing, duration, adherence), antiretroviral regimens (for HIV), vaccination status, treatment outcomes, resistance testing results
Molecular Profiling
Where available, data may include viral load measurements, viral genotype/subtype, drug resistance mutations, host genetic markers, cytokine profiles (IL-6, TNF-α, IP-10, sCD163, sCD14), antibody titers (anti-CMV IgG, anti-HPV antibodies), and transcriptomic or proteomic signatures8,9,10
Outcomes Data
Natural history progression, treatment response rates, viral suppression status, immunologic parameters (CD4 counts, CD8 counts for HIV), clinical complications, longitudinal follow-up data
Ethical Sourcing and Regulatory Compliance
Trust and compliance are fundamental to our operations.
Ethical standards:
- Institutional Review Board (IRB)-approved patient consent documentation
- Patients engaged through transparent, compliant recruitment and consent processes
- All samples from patients with confirmed infectious disease diagnoses
Regulatory & Data Security
- De-identified patient data in HIPAA-compliant format
- Certified quality management systems including ISO 9001, ISO 27001, ISO 27701 for information security and privacy11
- Full traceability from study design to receipt of samples
From Discovery to Therapy—Powering Every Step of Infectious Disease Research
Whether you're exploring viral pathogenesis, developing diagnostics, validating therapeutics, or advancing precision medicine approaches, our biospecimens support research across the infectious disease continuum:
Basic research
Investigate mechanisms of viral entry, replication, immune evasion, host-pathogen interactions, and viral persistence. Study viral evolution, mutation dynamics, and strain-specific pathogenicity.
Biomarker discovery & validation
Use longitudinal sets and matched controls to identify diagnostic, prognostic, or predictive markers. Validate inflammatory biomarkers (IL-6, sTNFR, sCD163), viral load assays, antibody responses, and immunosenescence signatures 12,13
Diagnostics development
Develop and validate assays for early detection, screening applications, point-of-care testing, or monitoring of COVID-19, HIV, hepatitis viruses, HPV, and CMV infections. Access validation sets with documented specificity and sensitivity requirements.
Therapeutic development
Support drug discovery and clinical validation with well-characterized patient samples. Access treatment-naïve and treatment-experienced cohorts, pre- and post-seroconversion samples, and specimens from patients on specific antiviral regimens.14,15
Vaccine Research
Evaluate vaccine immunogenicity, antibody responses, T-cell responses, and durability of protection. Access specimens from vaccinated and unvaccinated cohorts, including samples from the 2024-25 COVID-19 vaccine campaign targeting KP.2 and JN.1 variants.16
Precision Medicine
Leverage genomic profiling in samples linked to phenotypic and outcomes data to enable precision medicine approaches. Understand host genetic factors influencing susceptibility, natural history, and treatment response.
Featured Disease Areas
COVID-19 (SARS-CoV-2) Biospecimens
Access specimens from patients with confirmed COVID-19 infection, including acute phase samples, convalescent specimens, long-COVID cohorts, and vaccinated individuals. Available data includes viral variant information, vaccination status, symptom duration, and inflammatory biomarker profiles. Research shows continued importance of immune profiling and long-term sequelae studies even as COVID-19 transitions out of pandemic phase.17,18
Ready to Advance Your Genetic Disease Research?
Explore our extensive inventory of infectious disease biospecimens or contact our team to discuss custom collection services tailored to your research needs.
Our donor network across the United States supports research into COVID-19, HIV, Hepatitis B, Hepatitis C, HPV, CMV, and other infectious diseases. Whether you need cross-sectional or longitudinal collections, matched sample sets, or custom cohorts, we provide the precise specimens and deep annotation required from study design to receipt of samples.