(T cells, B cells, NK cells)
Improve consistency, efficiency, and quality with freshly collected immune cells
One partner for sample collection and cell isolation
Patients donate whole blood in the comfort of their own homes. T cells, B cells, and/or NK cells are isolated within 24 hours of venipuncture collection, cryopreserved, and stored in liquid nitrogen.
Typical viability and purity ≥95% (disease-dependent)
Negative or positive selection
Aliquots of 5-10 million cells
Maximize results with flexible study size, design, and scope:
- Procure PBMCs or plasma/serum concurrently with T cells
- Specify inclusion/exclusion criteria (e.g., CLIA confirmed hepatitis B/C, HIV negative)
- NGS Human Leukocyte Antigen (HLA) typing available
- Multiple time points or event-based collection with recallable patient community (>90% study retention)
Compliance & Quality Assured
Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval of all study protocols, specific study documentation, and study participant facing information. Both Advarra and WCG IRB are organized and operates in compliance with: FDA, OHRP, and International Conference on Harmonization (ICH).
Sanguine operates under an electronic informed consent process which executes 21 CFR part 11 compliant e-signatures, and Sanguine systems interacting with study participant information are HIPAA-compliant. Leukapheresis is conducted under an IRB-approved protocol at qualified blood clinic sites.
More than Biospecimen Procurement
Take advantage of our experienced and dedicated sample collection, logistics, processing, characterization, and storage capabilities to optimize and streamline your study design and mitigate unnecessary variability.
Publications using Sanguine PBMCs:
Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
ZBTB2 represses HIV-1 transcription and is
regulated by HIV-1 Vpr
and cellular DNA damage responses