Healthy Serum

About Healthy Serum

Healthy Human Serum for Control and Reference Research

Our Healthy Serum is sourced from IRB-consented, clinically screened healthy donors. Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality as baseline and control material for immunology, clinical chemistry, and biomarker studies. Aliquot volumes are configured per project and reported per lot. Healthy plasma is also available where an anticoagulated matrix is required.

Why Serum from Healthy Donors

Serum is the liquid fraction remaining after whole blood has been allowed to clot and the clot removed. That single processing difference determines what serum is good for, and it is the reason serum and plasma are not interchangeable in a study design.

• Because fibrinogen and the clotting factors are consumed during coagulation, serum is a lower-complexity protein matrix than plasma, which reduces interference in many immunoassay and mass spectrometry workflows.
• Clot formation releases platelet contents into the fluid, so serum concentrations of platelet-derived mediators differ systematically from plasma — a difference that must be controlled, not ignored, when comparing datasets.
• Serum is the conventional matrix for most clinical chemistry panels, hormone assays, and infectious disease serology, so healthy serum is the natural comparator when a candidate assay is intended to sit alongside standard-of-care testing.
• Healthy serum defines the baseline against which a disease-state signal is measured; without a contemporaneously collected, identically processed control arm, an apparent biomarker difference may reflect handling rather than biology.
• Serum from screened donors with no active disease supports establishment of reference ranges and normal distributions for candidate analytes.
• Because our healthy and disease-state collections run under the same protocols and processing windows, pre-analytical variables are held constant across the comparison.

Donor Stratification Available

• Age band and sex assigned at birth, for demographic matching to a disease cohort
• Race and ethnicity
• Body mass index and smoking status where captured
• Medication-free donors, or donors on defined medication classes
• Infectious disease screening results, including viral serostatus where documented
• Blood type and HLA typing available on request for selected inventory
• Cohorts matched to a specific disease-state collection available on request

Product Features

• Collected from clinically screened healthy donors
• Research Use Only (RUO)
• Processed and frozen within 24 hours of collection
• IRB-approved protocols with documented consent
• Custom aliquot volumes available upon request
• Volumes and lot-specific processing details reported per lot

De-identified Donor Data

• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• Donor-reported medication use and comorbidity screening
• Additional demographic and screening metadata available on request

Applications

• Matched control arms for disease-state biomarker discovery and validation
• Serum cytokine, chemokine, and protein profiling
• Reference range and normal distribution establishment for candidate analytes
• Immunoassay development, calibration, and specificity testing
• Proteomic and metabolomic baseline characterisation
• Serology assay controls and negative comparator material
• Cell culture supplementation with human serum where autologous or human-origin serum is required
• Controls for therapeutic candidate screening and validation

Other Healthy Donor Specimen Types

• Healthy Plasma
• Healthy Whole Blood
• Healthy PBMC
• Healthy Leukopak
• Healthy Bulk Plasma
• Healthy Skin Punch Biopsy

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Healthy serum is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse other donor cohorts and collection formats, visit our human serum page.