APECED Plasma
Powered by BiozAbout:APECED Plasma - Cryopreserved human APECED plasma collected from clinically confirmed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) donors. APECED plasma is ideal for endocrine dysfunction and APECED therapeutic development.
About APECED Plasma
APECED Plasma | Human Plasma from Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) Donors
APECED Plasma is collected from donors clinically diagnosed with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, also known as APS-1) and processed within hours of collection to preserve key analytes such as cytokines, proteins, and metabolites. APECED is caused by biallelic AIRE mutations that break central immune tolerance, producing the characteristic triad of hypoparathyroidism, adrenal insufficiency, and chronic mucocutaneous candidiasis, along with high-titre anti-interferon-ω and anti-IL-22 autoantibodies. This human plasma supports research focused on endocrine dysfunction, autoantibody profiling, and APECED therapeutic development.
Product Features
- Research Use Only (RUO)
- APECED plasma collected from clinically confirmed APECED donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
De-identified Donor Data
- Verified Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) diagnosis
- AIRE genotype where available
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Additional APECED-specific metadata available
Applications
- Anti-interferon-ω and anti-IL-22 autoantibody profiling
- Biomarker discovery and validation
- Cytokine and inflammation profiling
- Metabolomics and proteomics studies
- Therapeutic response research
Other APECED Specimen Types
APECED donor material is also available as APECED PBMC, APECED serum, and APECED whole blood. If you need an APECED leukopak or another apheresis-derived cell product, we can arrange a custom collection — see our human leukopak page for specifications and current availability, or contact us to scope a disease-specific leukopak draw.
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering and Customization
APECED plasma is available in standard and custom volumes. For international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Plasma are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Healthy Plasma
216 In Stock View InventoryNeed a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.