Covid-19 Vaccinated Plasma
Covid-19 Vaccinated Plasma - human plasma from donors with confirmed COVID-19 vaccination history, processed within 24 hours. Ideal for neutralizing antibody titers, vaccine platform comparison, hybrid immunity research, and variant cross-reactivity studies. Stratification by vaccine platform, dose count, booster history, and prior infection status.
Covid-19 Vaccinated Plasma for Vaccine Immunogenicity Research
Our Covid-19 Vaccinated Plasma is sourced from IRB-consented donors with a confirmed COVID-19 vaccination history. Each sample is processed and frozen within 24 hours of collection to preserve circulating antibodies, cytokines, and coagulation-relevant proteins for downstream vaccine immunogenicity and immune response research.
Covid-19 Vaccination Biology and Why Plasma
- SARS-CoV-2 vaccines, including mRNA (BNT162b2, mRNA-1273), viral vector, and protein subunit platforms, elicit spike-protein-specific antibody and T-cell responses that vary in magnitude and durability by platform, dose number, and time since vaccination.
- Neutralizing antibody titers, spike-specific IgG, and IgA responses are central readouts for vaccine immunogenicity studies and for assessing protection against emerging variants.
- Plasma preserves coagulation factors and complement components alongside antibody titers, supporting studies of rare vaccine-associated hematologic events as well as routine immunogenicity endpoints.
- Hybrid immunity – the combination of vaccination and prior infection – produces distinct antibody breadth and durability profiles compared to vaccination alone, making vaccination and infection history jointly important donor variables.
- Waning antibody titers over time and the emergence of immune-evasive variants have driven ongoing demand for updated bivalent and variant-specific booster response data.
Donor Stratification Available
- Vaccine platform and manufacturer (mRNA, viral vector, protein subunit)
- Number of doses and time since most recent dose
- Booster history, including bivalent or variant-specific boosters
- Prior SARS-CoV-2 infection history (hybrid immunity status)
- Age band and sex assigned at birth
- Matched unvaccinated donors available on request
Product Features
- Collected from donors with confirmed COVID-19 vaccination history
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- IRB-approved protocols with documented consent
- Standard and custom aliquot volumes available
De-identified Donor Data
- Vaccination confirmation, platform, and dose history
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- Prior infection history where documented
- Additional vaccination-specific metadata available on request
Applications
- Neutralizing antibody and spike-specific IgG/IgA titer studies
- Vaccine platform comparison and durability studies
- Hybrid immunity and breakthrough infection research
- Variant cross-reactivity and immune escape assessment
- Assay development and validation for antibody and cytokine panels
Other Covid-19 Vaccinated Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Covid-19 vaccinated plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human plasma page.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.