Diabetic Kidney Disease (DKD) Plasma
Diabetic Kidney Disease (DKD) Plasma - human plasma from clinically confirmed DKD donors, processed within 24 hours. DKD is a leading complication of diabetes driven by chronic hyperglycemia damaging the glomerular filtration barrier. Ideal for renal biomarker profiling (cystatin C, KIM-1, NGAL), inflammatory marker studies, and pharmacodynamic monitoring of SGLT2 inhibitors, GLP-1 agonists, and nonsteroidal MRAs. Stratification by diabetes type, CKD stage, and albuminuria status.
Diabetic Kidney Disease (DKD) Plasma for Renal Biomarker Research
Our Diabetic Kidney Disease (DKD) Plasma is sourced from IRB-consented donors clinically diagnosed with diabetic kidney disease, a progressive complication of diabetes and a leading cause of end-stage renal disease. Each sample is processed and frozen within 24 hours of collection to preserve circulating renal biomarkers, inflammatory mediators, and metabolic markers relevant to disease pathophysiology.
DKD Biology and Why Plasma
- Chronic hyperglycemia drives glomerular hyperfiltration, mesangial matrix expansion, and podocyte injury, producing progressive proteinuria/albuminuria and a gradual decline in estimated glomerular filtration rate (eGFR).
- Plasma is the preferred matrix for renal injury and filtration biomarkers including cystatin C, KIM-1 (kidney injury molecule-1), and NGAL (neutrophil gelatinase-associated lipocalin), which can detect tubular injury earlier than creatinine-based measures.
- Low-grade chronic inflammation, reflected in circulating TNF receptor and inflammatory cytokine levels, is increasingly recognized as a driver of DKD progression independent of glycemic control.
- Renoprotective therapies including SGLT2 inhibitors, GLP-1 receptor agonists, and the nonsteroidal mineralocorticoid receptor antagonist finerenone have shifted the treatment landscape, creating demand for biomarkers that track renal protection and disease-modifying response.
- Disease staging by CKD stage and albuminuria category (A1/A2/A3) is central to both natural history and treatment-response research.
Donor Stratification Available
- Diabetes type (Type 1 or Type 2) and duration
- CKD stage and eGFR at collection
- Albuminuria category (normo-, micro-, macroalbuminuric)
- Treatment history, including SGLT2 inhibitors, GLP-1 agonists, and MRAs
- Comorbid hypertension and cardiovascular disease status
- Age band and sex assigned at birth
- Matched healthy and diabetic-without-kidney-disease controls available
Product Features
- Collected from clinically confirmed DKD donors
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- IRB-approved protocols with documented consent
- Standard and custom aliquot volumes available
De-identified Donor Data
- DKD diagnosis confirmation, CKD stage, and albuminuria category
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- Diabetes type, duration, and treatment history where documented
- Additional DKD-specific metadata available on request
Applications
- Renal injury biomarker profiling (cystatin C, KIM-1, NGAL)
- Inflammatory marker studies in CKD progression
- Pharmacodynamic monitoring for SGLT2 inhibitors, GLP-1 agonists, and finerenone
- Biomarker development for early detection and staging
- Diabetes-CKD comorbidity research
Other Diabetic Kidney Disease Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Diabetic kidney disease plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human plasma page.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.