Alopecia Areata Plasma

Alopecia Areata Plasma for Autoimmune and Cytokine Research

Our Alopecia Areata Plasma is sourced from IRB-consented donors clinically diagnosed with alopecia areata (AA), an autoimmune condition in which the immune system attacks hair follicles and causes patchy, and sometimes complete, hair loss. Each sample is processed and frozen within 24 hours of collection to preserve circulating cytokines, chemokines, and biomarker proteins for downstream immunology and drug development research.

Alopecia Areata Biology and Why Plasma

• Alopecia areata is a T-cell-mediated autoimmune disease in which cytotoxic CD8+ NKG2D+ T cells collapse the hair follicle’s immune privilege, triggering an interferon-gamma-driven inflammatory cascade around the follicle bulb.
• The IFN-gamma / JAK-STAT signaling axis is central to disease activity, which is why JAK inhibitors have become a primary therapeutic class; circulating JAK-STAT pathway markers and interferon-induced chemokines (including CXCL9, CXCL10, and CXCL11) are of particular research interest.
• Genome-wide association studies link alopecia areata to other autoimmune conditions, and patients frequently show elevated circulating autoantibodies and shifts in Th1/Th17 cytokine balance.
• Plasma is the appropriate matrix for capturing labile clotting-pathway proteins, complement components, and cytokines in their circulating state, complementing cellular AA specimens used for lymphocyte phenotyping.
• Disease subtypes – patchy AA, alopecia totalis, and alopecia universalis – can show differing severity of systemic immune activation, supporting stratified biomarker studies.

Donor Stratification Available

• AA subtype: patchy, totalis (complete scalp), or universalis (complete body)
• Disease duration and number of prior relapse/remission episodes
• Severity of Alopecia Tool (SALT) score where available
• Treatment history, including JAK inhibitor, corticosteroid, or immunotherapy exposure
• Family history of alopecia areata or other autoimmune disease
• Age band and sex assigned at birth
• Matched healthy controls available

Product Features

• Collected from clinically confirmed alopecia areata donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• IRB-approved protocols with documented consent
• Standard and custom aliquot volumes available

De-identified Donor Data

• Alopecia areata diagnosis confirmation
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• AA subtype, severity, and treatment history where documented
• Additional AA-specific metadata available on request

Applications

• Cytokine and chemokine profiling of the IFN-gamma / JAK-STAT axis
• Autoantibody discovery and validation
• Biomarker development for disease activity and relapse prediction
• Pharmacodynamic and target-engagement assay development for JAK inhibitors and other immunomodulators
• Untargeted proteomic and multiplex immunoassay studies
• Stratified cohort assembly for treatment-response studies

Other Alopecia Areata Specimen Types

• Alopecia Areata Serum
• Alopecia Areata Whole Blood
• Alopecia Areata PBMC
• Alopecia Areata Leukopak

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Alopecia areata plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human plasma page.