Alopecia Areata Plasma
Powered by BiozAbout:Alopecia Areata Plasma - human plasma from clinically confirmed AA donors, processed within 24 hours. Alopecia areata is a T-cell-mediated autoimmune disease driving hair follicle attack via the IFN-gamma/JAK-STAT axis. Ideal for cytokine profiling, autoantibody discovery, and JAK inhibitor pharmacodynamic studies. Stratification by AA subtype, SALT score, and treatment history; matched healthy controls available.
About Alopecia Areata Plasma
Alopecia Areata Plasma for Autoimmune and Cytokine Research
Our Alopecia Areata Plasma is sourced from IRB-consented donors clinically diagnosed with alopecia areata (AA), an autoimmune condition in which the immune system attacks hair follicles and causes patchy, and sometimes complete, hair loss. Each sample is processed and frozen within 24 hours of collection to preserve circulating cytokines, chemokines, and biomarker proteins for downstream immunology and drug development research.
Alopecia Areata Biology and Why Plasma
- Alopecia areata is a T-cell-mediated autoimmune disease in which cytotoxic CD8+ NKG2D+ T cells collapse the hair follicle’s immune privilege, triggering an interferon-gamma-driven inflammatory cascade around the follicle bulb.
- The IFN-gamma / JAK-STAT signaling axis is central to disease activity, which is why JAK inhibitors have become a primary therapeutic class; circulating JAK-STAT pathway markers and interferon-induced chemokines (including CXCL9, CXCL10, and CXCL11) are of particular research interest.
- Genome-wide association studies link alopecia areata to other autoimmune conditions, and patients frequently show elevated circulating autoantibodies and shifts in Th1/Th17 cytokine balance.
- Plasma is the appropriate matrix for capturing labile clotting-pathway proteins, complement components, and cytokines in their circulating state, complementing cellular AA specimens used for lymphocyte phenotyping.
- Disease subtypes – patchy AA, alopecia totalis, and alopecia universalis – can show differing severity of systemic immune activation, supporting stratified biomarker studies.
Donor Stratification Available
- AA subtype: patchy, totalis (complete scalp), or universalis (complete body)
- Disease duration and number of prior relapse/remission episodes
- Severity of Alopecia Tool (SALT) score where available
- Treatment history, including JAK inhibitor, corticosteroid, or immunotherapy exposure
- Family history of alopecia areata or other autoimmune disease
- Age band and sex assigned at birth
- Matched healthy controls available
Product Features
- Collected from clinically confirmed alopecia areata donors
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- IRB-approved protocols with documented consent
- Standard and custom aliquot volumes available
De-identified Donor Data
- Alopecia areata diagnosis confirmation
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- AA subtype, severity, and treatment history where documented
- Additional AA-specific metadata available on request
Applications
- Cytokine and chemokine profiling of the IFN-gamma / JAK-STAT axis
- Autoantibody discovery and validation
- Biomarker development for disease activity and relapse prediction
- Pharmacodynamic and target-engagement assay development for JAK inhibitors and other immunomodulators
- Untargeted proteomic and multiplex immunoassay studies
- Stratified cohort assembly for treatment-response studies
Other Alopecia Areata Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Alopecia areata plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human plasma page.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Plasma are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Pair with a Healthy Control
Match your Alopecia Areata Plasma with normal donor samples for comparison
Healthy Plasma
216 In Stock View InventoryNeed a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.