Alopecia Areata Serum
Powered by BiozAbout:Alopecia Areata Serum - human serum from clinically confirmed AA donors, processed within 24 hours. Alopecia areata is a T-cell-mediated autoimmune disease driving hair follicle attack via the IFN-gamma/JAK-STAT axis. Ideal for autoantibody discovery, cytokine profiling, and JAK inhibitor pharmacodynamic studies. Stratification by AA subtype, SALT score, and treatment history; matched healthy controls available.
About Alopecia Areata Serum
Alopecia Areata Serum for Autoimmune and Biomarker Research
Our Alopecia Areata Serum is sourced from IRB-consented donors clinically diagnosed with alopecia areata (AA), an autoimmune condition in which the immune system attacks hair follicles, causing patchy or complete hair loss. Each sample is processed and frozen within 24 hours of collection to preserve serum proteins, autoantibodies, and cytokines for downstream immunology and biomarker research.
Alopecia Areata Biology and Why Serum
- Alopecia areata is a T-cell-mediated autoimmune disease in which cytotoxic CD8+ NKG2D+ T cells collapse the hair follicle’s immune privilege, triggering an interferon-gamma-driven inflammatory cascade.
- The IFN-gamma / JAK-STAT signaling axis drives disease activity, making JAK inhibitors a primary therapeutic class; serum interferon-induced chemokines (CXCL9, CXCL10, CXCL11) are widely used activity biomarkers.
- Patients frequently show circulating autoantibodies and altered Th1/Th17 cytokine balance detectable in serum.
- Serum, free of clotting factors, is preferred for autoantibody titers, complement studies, and many commercial immunoassay platforms validated on serum matrices.
- Disease subtypes – patchy AA, alopecia totalis, and alopecia universalis – can present with differing systemic immune activation, supporting stratified biomarker studies.
Donor Stratification Available
- AA subtype: patchy, totalis (complete scalp), or universalis (complete body)
- Disease duration and number of prior relapse/remission episodes
- Severity of Alopecia Tool (SALT) score where available
- Treatment history, including JAK inhibitor, corticosteroid, or immunotherapy exposure
- Family history of alopecia areata or other autoimmune disease
- Age band and sex assigned at birth
- Matched healthy controls available
Product Features
- Collected from clinically confirmed alopecia areata donors
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- IRB-approved protocols with documented consent
- Standard and custom aliquot volumes available
De-identified Donor Data
- Alopecia areata diagnosis confirmation
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- AA subtype, severity, and treatment history where documented
- Additional AA-specific metadata available on request
Applications
- Autoantibody discovery and validation
- Cytokine and chemokine profiling of the IFN-gamma / JAK-STAT axis
- Biomarker development for disease activity and relapse prediction
- Pharmacodynamic assay development for JAK inhibitors and other immunomodulators
- Immunoassay platform bridging and reference-range establishment
Other Alopecia Areata Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Alopecia areata serum is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human serum page.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Serum
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Pair with a Healthy Control
Match your Alopecia Areata Serum with normal donor samples for comparison
Healthy Serum
100 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.