Hypothyroidism Plasma

About Hypothyroidism Plasma

Hypothyroidism Plasma for Research

Hypothyroidism Plasma is collected from donors clinically diagnosed with hypothyroidism and processed within hours of collection to preserve key analytes such as hormones, autoantibodies, proteins, and metabolites. This human plasma supports thyroid function assay development, autoantibody research, and biomarker discovery in thyroid disease.

Identify the Cause, Not Just the Deficiency

Hypothyroidism describes insufficient thyroid hormone action, but the underlying cause changes what a sample can tell you:

• Autoimmune (Hashimoto’s thyroiditis) — by far the most common cause in iodine-sufficient populations, characterised by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) autoantibodies. For a dedicated cohort see Hashimoto’s disease plasma.
• Post-ablative or post-surgical — following radioiodine or thyroidectomy; typically autoantibody-negative
• Drug-induced — including amiodarone and lithium
• Central (secondary) — pituitary or hypothalamic in origin, with low TSH rather than high

Severity also matters: subclinical hypothyroidism (raised TSH with normal free T4) and overt hypothyroidism behave differently in biomarker studies, as does treatment status — most donors on levothyroxine are biochemically euthyroid at the time of draw, which is either exactly what you want or exactly what you must exclude.

Donor Stratification Available

• Thyroid function — TSH, free T4, and free T3 values where tested
• Autoantibody status — anti-TPO and anti-Tg where tested
• Aetiology — autoimmune, post-ablative, post-surgical, drug-induced, central
• Severity — subclinical vs overt
• Treatment status — untreated, or on levothyroxine with dose and duration
• Matched euthyroid controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed hypothyroidism donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified hypothyroidism diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Additional hypothyroidism-specific metadata available

Applications

• Thyroid function immunoassay development and validation (TSH, FT4, FT3)
• Anti-TPO and anti-Tg autoantibody assay work
• Biomarker discovery and validation
• Metabolomic and lipid profiling in thyroid dysfunction
• Cardiovascular and metabolic comorbidity research
• Therapeutic response research

Other Hypothyroidism Specimen Types

Matched material is available as hypothyroidism serum — generally preferred for hormone immunoassays — plus whole blood, PBMC, and leukopak. Related thyroid cohorts include Graves’ disease.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering and Customization

Hypothyroidism plasma is available in standard and custom volumes. For international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.