Psoriatic Arthritis Leukopak

About Psoriatic Arthritis Leukopak

High-Yield LeukoCore Psoriatic Arthritis Leukopaks for Immune-Mediated Inflammatory Disease Research

LeukoCore Psoriatic Arthritis Leukopak biospecimens are collected from IRB-consented donors clinically diagnosed with psoriatic arthritis through IRB-approved apheresis procedures, then processed and shipped within 24 hours of collection. Each leukopak contains large quantities of peripheral blood mononuclear cells (PBMCs). Psoriatic arthritis is a seronegative, immune-mediated inflammatory disease of the IL-23/IL-17 axis – it is not autoantibody-driven – and high-yield leukocyte material supports the cellular immunology that this mechanism demands.

Psoriatic Arthritis Immunology and Why a Leukopak

• Psoriatic arthritis belongs to the seronegative spondyloarthritis family. Rheumatoid factor and anti-citrullinated protein antibodies are characteristically absent, so the rheumatoid arthritis autoantibody framework does not apply and should not be imported.
• The central pathogenic pathway runs from IL-23 through Th17 and related innate-like lymphocyte populations to IL-17A, IL-17F, and IL-22, with TNF contributing throughout. This is validated by the efficacy of IL-17, IL-23, and TNF inhibitors in the disease.
• Characteristic lesions include enthesitis at tendon and ligament insertions, dactylitis, nail disease, and both bone erosion and new bone formation – a combination of destructive and proliferative change that distinguishes it from rheumatoid arthritis.
• HLA-B27 is associated particularly with axial involvement, while HLA-C*06:02 associates with the cutaneous psoriasis phenotype, and the two patterns can be used to stratify donors.
• Innate-like and tissue-homing lymphocyte subsets – including gamma-delta T cells, mucosal-associated invariant T cells, and CCR6+ Th17 populations – are present at low frequency in blood, which is precisely why apheresis-scale material is required to isolate and study them.
• Leukopaks deliver the cell numbers needed for multi-arm functional assays, rare-subset sorting, and single-cell studies that cannot be powered from a standard venous draw.

Donor Stratification Available

• Disease pattern: peripheral oligoarticular or polyarticular versus axial involvement
• Presence of enthesitis, dactylitis, and nail psoriasis
• Concomitant cutaneous psoriasis and its severity where documented
• Treatment exposure: bDMARD-naive, anti-TNF, anti-IL-17, anti-IL-23/IL-12-23, or JAK inhibitor treated; conventional DMARD background
• Disease activity at collection and disease duration
• HLA-B27 status where typing is available; age band and sex
• Matched healthy controls available

Product Features

• Research Use Only (RUO) human leukopaks
• Clinically confirmed psoriatic arthritis donors
• High cell yield for large-scale studies
• Processed and shipped within 24 hours of collection
• Fresh or cryopreserved options available
• IRB-approved and ethically sourced
• Infectious disease testing
• HLA-A typing
• Screen donors with LeukoLot™

De-identified Donor Data

• Verified psoriatic arthritis diagnosis from healthcare providers
• Donor demographics: age, sex assigned at birth, race/ethnicity
• Self-reported medication history and allergies
• Relevant clinical data, including disease pattern, activity, and treatment history where documented

Applications

• Immunophenotyping of Th17, Tc17, gamma-delta T-cell, and MAIT populations by spectral or conventional flow cytometry
• Cell sorting of rare tissue-homing and innate-like lymphocyte subsets
• IL-23/IL-17 axis functional assays, including stimulation and cytokine release profiling
• Ex vivo drug screening and mechanism-of-action work for IL-17, IL-23, TNF, and JAK-targeted agents
• Single-cell RNA sequencing, CITE-seq, and TCR repertoire analysis
• Osteoclast differentiation assays from donor-derived monocytes to model bone erosion
• Biomarker discovery and validation for treatment response and disease activity
• Large matched cell lot banking for multi-site or longitudinal spondyloarthritis studies

Other Psoriatic Arthritis Specimen Types

• Psoriatic Arthritis PBMC
• Psoriatic Arthritis Plasma
• Psoriatic Arthritis Serum
• Psoriatic Arthritis Whole Blood
• Psoriatic Arthritis Synovial Fluid
• Psoriatic Arthritis Skin Punch Biopsy
• Psoriatic Arthritis Bulk Plasma

Compliance and Quality Assurance

• Collected under IRB oversight with donor e-consent (21 CFR Part 11 compliant)
• HIPAA-compliant handling of donor information
• Rigorous donor screening and documentation

Ordering & Customization

Psoriatic Arthritis Leukopak is available fresh or cryopreserved. For pricing, international shipping, or regulatory documentation, please contact learnmore@sanguinebio.com to confirm regional compliance and shipping availability. Need a different condition, or want to check current availability across our full inventory? Visit our human leukopak page to browse other disease-state options and live stock status.