Rosacea PBMC

About Rosacea PBMC

Rosacea PBMC for Innate Immune and Inflammatory Dermatology Research

Rosacea PBMC are isolated from the peripheral blood of IRB-consented donors with a clinically confirmed diagnosis of rosacea, cryopreserved in CryoStor® CS10 and processed within 24 hours of collection. These peripheral blood mononuclear cells provide a viable immune cell population for characterising the innate immune component of rosacea, alongside subtype-annotated donor metadata.

Neurovascular and Innate Immune Mechanisms in Rosacea

Rosacea is a chronic inflammatory facial dermatosis best understood as a combination of neurovascular dysregulation and innate immune activation. It is not an autoimmune disease and has no associated autoantibody; the mechanisms below are the ones with genuine support in the literature.

• Cathelicidin peptide processing is central: elevated kallikrein-5 activity generates abnormal LL-37 fragments in rosacea skin, and these fragments are proinflammatory and vasoactive.
• Transient receptor potential channels, including TRPV1 and TRPA1, mediate the neurogenic flushing, burning and stinging responses to heat, alcohol, spicy food and other recognised triggers.
• Innate immune receptors such as TLR2 are upregulated in rosacea skin and link environmental and microbial stimuli to the cathelicidin pathway.
• Increased Demodex folliculorum density is a consistent finding, particularly in papulopustular disease, and is thought to act as an innate immune stimulus rather than a classical infection.
• Mast cells are abundant in rosacea skin and sit at the interface between neuropeptide signalling and vascular and inflammatory change.
• Rosacea is fundamentally a localised cutaneous disorder, so PBMC are appropriate for characterising the circulating innate immune compartment and its reactivity to defined stimuli — not as a substitute for lesional skin. Used with that scope in mind, they support monocyte and dendritic cell phenotyping, TLR ligand stimulation and cytokine response assays.

Donor Stratification Available

• Subtype/phenotype: erythematotelangiectatic, papulopustular, phymatous, or ocular rosacea
• Severity grading where documented
• Predominant clinical features: persistent erythema, flushing, telangiectasia, papules and pustules
• Treatment status: topical metronidazole, azelaic acid, ivermectin, brimonidine, oral tetracycline-class antibiotic, isotretinoin, or treatment-naive
• Trigger sensitivity profile and disease duration where documented
• Ocular involvement and comorbid dermatological conditions where documented
• Matched healthy controls available

Product Features

• Research Use Only (RUO), cryopreserved PBMCs
• Clinically confirmed rosacea donors
• Available in cell counts ranging from 5 million to 2 billion
• Processed within 24 hours of collection
• Stored using CryoStor® CS10 freezing media
• Viability and recovery reported per lot
• IRB-approved protocols and electronic informed consent
• Screen LeukoLot™ available prior to bulk orders

De-identified Donor Data

• Verified rosacea diagnosis and subtype where documented
• Donor demographics: age, sex assigned at birth, race/ethnicity
• Current and prior rosacea treatment history
• Self-reported allergies and infectious disease history
• Additional rosacea-specific data available upon request

Applications

• Innate immune cell characterisation and immunophenotyping in rosacea donors
• Monocyte and dendritic cell phenotyping and activation state analysis
• TLR ligand ex vivo stimulation and cytokine response assays
• Cathelicidin and kallikrein pathway studies in circulating immune cells
• Transcriptomic and single-cell profiling of the peripheral immune compartment
• Subtype-stratified comparative immune studies
• Target validation and screening for anti-inflammatory dermatology candidates
• Case-control study design with matched healthy donor material

Other Rosacea Specimen Types

• Rosacea Plasma
• Rosacea Bulk Plasma
• Rosacea Serum
• Rosacea Whole Blood
• Rosacea Leukopak

Compliance and Quality Assurance

• IRB-approved collections and protocols
• 21 CFR Part 11-compliant e-consent system
• HIPAA-compliant donor data protection
• Documentation support available for regulatory review

Ordering & Customization

Rosacea PBMC samples are shipped on dry ice and available in custom aliquots. For pricing, current availability, international orders or regulatory documentation, contact learnmore@sanguinebio.com. To browse disease-state options and live stock status across our full PBMC inventory, visit our human PBMC page.