Ulcerative Colitis CD56+ NK Cells

About Ulcerative Colitis CD56+ NK Cells

Ulcerative Colitis CD56+ NK Cells for Mucosal Immunology Research

Ulcerative Colitis CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with ulcerative colitis. These CD56+ CD3− natural killer cells reflect disease-associated innate immune alterations and support studies of immune surveillance, inflammation, and cytotoxicity.

NK Cells in Ulcerative Colitis

Ulcerative colitis is an immune-mediated inflammatory bowel disease characterised by continuous mucosal inflammation confined to the colon, driven by a dysregulated response to intestinal microbiota rather than autoimmunity against a defined self-antigen. The innate lymphocyte compartment is closely involved:

• ILC plasticity — the innate lymphoid compartment shifts toward IFN-γ-producing ILC1-like and IL-17-producing ILC3 phenotypes in inflamed mucosa, and NK cells overlap phenotypically with ILC1
• Altered cytotoxicity and receptor repertoire in circulating NK cells
• Pro-inflammatory cytokine production — IFN-γ and TNF-α contributing to epithelial damage
• Dual regulatory and inflammatory roles, depending on subset and mucosal context
• Epithelial barrier interaction — relevant to the colonic-restricted pattern that distinguishes UC from Crohn’s
• Trafficking-directed therapy — vedolizumab blocks α4β7 integrin, altering circulating lymphocyte populations in treated donors

Donor Stratification Available

• Disease activity — Mayo score, UCEIS, or partial Mayo where recorded; active flare vs remission
• Disease extent — proctitis, left-sided colitis, or pancolitis
• Inflammatory markers — CRP and faecal calprotectin where available
• pANCA serology where tested
• Treatment status — 5-ASA, thiopurine, anti-TNF, anti-integrin, or JAK inhibitor
• Matched healthy controls, and Crohn’s disease donors for differential IBD comparison

Product Features

• Research Use Only (RUO), CD56+ enriched NK cells
• Isolated from clinically diagnosed ulcerative colitis donors
• High viability and enrichment
• Cryopreserved in CryoStor® CS10 media
• Processed within 24 hours of collection
• Flow cytometry purity and viability data per lot
• Ethically sourced with IRB approval and HIPAA compliance

De-identified Donor Data

• Confirmed diagnosis of ulcerative colitis
• Demographics: age, sex assigned at birth, race/ethnicity
• Self-reported clinical history and medication use

Applications

• NK cell phenotype and function studies in ulcerative colitis
• ILC plasticity and ILC1/ILC3 differentiation research
• Cytotoxicity, degranulation, and CD56-bright/dim subset analysis
• Mucosal immune surveillance and epithelial interaction studies
• Differential IBD studies — UC vs Crohn’s disease
• Biologic mechanism-of-action research
• Single-cell analysis and biomarker identification
• Preclinical immunotherapy development

Other Ulcerative Colitis Specimen Types

Matched material is available as UC CD19+ B cells and UC leukopak. For the broader category see inflammatory bowel disease CD56+ NK cells.

Compliance and Quality Assurance

• IRB-approved collection and 21 CFR Part 11-compliant e-consent
• Standardized processing and quality protocols
• HIPAA-compliant data handling

Ordering & Customization

Ulcerative Colitis CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.