Asthma Plasma
Powered by BiozAbout:Asthma Plasma is collected from IRB-consented donors with clinically confirmed asthma. Ideal for type 2 cytokine profiling, IgE quantification, eosinophil-associated soluble markers, and endotype-resolved biomarker research. Available stratified by severity, allergic versus non-allergic phenotype, eosinophil count and treatment tier, with matched healthy controls.
About Asthma Plasma
Asthma Plasma for Airway Inflammation and Type 2 Immunity Research
Asthma Plasma is collected from IRB-consented donors clinically diagnosed with asthma and processed within one day of collection to preserve cytokines, proteins and metabolites. Plasma is acellular, so this product is intended for soluble-analyte measurement rather than cell-based assays.
Asthma Endotypes and Why Plasma
Asthma is a chronic inflammatory airway disease characterised by variable airflow obstruction and airway hyperresponsiveness. It is not an autoimmune disease. Modern asthma research is organised around endotypes rather than a single mechanism.
- Type 2 high asthma is driven by IL-4, IL-5 and IL-13 signalling, with eosinophilic airway inflammation and IgE-mediated sensitisation to inhaled allergens
- Total and allergen-specific IgE, along with type 2 cytokines and eosinophil-associated proteins, are measurable in plasma and underpin patient selection for biologic therapies
- Non-type 2 asthma encompasses neutrophilic and paucigranulocytic patterns, is more often associated with obesity, smoking or later onset, and typically responds poorly to type 2 targeted biologics
- Airway remodelling, including smooth muscle hypertrophy and subepithelial fibrosis, contributes to fixed obstruction in longstanding disease
- Because sputum and bronchoscopy are impractical at scale, plasma is the workhorse matrix for endotype-associated soluble markers and for pharmacodynamic readouts in biologic development
- Plasma supports multiplex cytokine panels, specific IgE testing, proteomics and metabolomics from a single acellular sample
Donor Stratification Available
- Severity: mild, moderate, or severe asthma by clinical assessment
- Allergic versus non-allergic asthma
- Blood eosinophil count band where available
- Treatment tier: inhaled corticosteroid alone, combination controller therapy, or on a type 2 targeted biologic
- Comorbid atopic conditions such as allergic rhinitis, atopic dermatitis, or nasal polyposis
- Smoking status and exacerbation history
- Matched healthy controls available
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed asthma donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
- Anticoagulant selection available on request to match your assay
De-identified Donor Data
- Verified asthma diagnosis
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Severity and controller therapy information where recorded
- Additional asthma-specific metadata available
Applications
- Type 2 cytokine profiling, including IL-4, IL-5 and IL-13 pathway markers
- Total and allergen-specific IgE quantification
- Eosinophil-associated soluble marker measurement
- Endotype-resolved biomarker discovery and validation
- Plasma proteomics and metabolomics in airway disease
- Pharmacodynamic and target engagement work for respiratory biologics
- Allergy and asthma diagnostic assay development
- Case-control comparisons against matched healthy donors
Other Asthma Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Asthma plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse plasma from other disease states and check live stock status, visit our human plasma page.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Plasma are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Pair with a Healthy Control
Match your Asthma Plasma with normal donor samples for comparison
Healthy Plasma
216 In Stock View InventoryNeed a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.