Asthma Serum

About Asthma Serum

Asthma Serum for Type 2 Airway Inflammation Research

Our Asthma Serum is sourced from IRB-consented donors clinically diagnosed with asthma, with each sample processed and frozen within 24 hours of collection. Asthma is a chronic inflammatory airway disease characterised by variable airflow obstruction and bronchial hyperresponsiveness. In most patients the underlying immunology is type 2 — allergic sensitisation driving IL-4, IL-5 and IL-13 signalling, eosinophilia and IgE production — rather than autoimmune. Serum is the standard matrix for the analytes that define that endotype.

Why Serum for Asthma

Asthma is no longer treated as one disease. Endotyping — separating type 2-high from type 2-low inflammation — now determines which biologic a patient receives, and the measurements that drive that decision are largely serum measurements.

• Total and allergen-specific IgE — serum is the standard matrix for both. Total IgE guides anti-IgE therapy dosing eligibility, and allergen-specific IgE defines the sensitisation profile underlying allergic asthma.
• The type 2 cytokine axis — IL-4, IL-5 and IL-13 are the validated drug targets in severe eosinophilic and allergic asthma, addressed by anti-IL-5, anti-IL-5 receptor and anti-IL-4 receptor alpha biologics. Serum supports research into circulating correlates of those pathways.
• Epithelial alarmin biology — TSLP is an upstream epithelial-derived driver of both type 2 and non-type 2 inflammation and is now a validated therapeutic target, making upstream airway-epithelial biology an active serum research area.
• Eosinophil-derived proteins — eosinophil cationic protein and related granule proteins reflect eosinophil activation rather than simply eosinophil count.
• Type 2-low endotypes matter too — a substantial minority of asthma is neutrophilic or paucigranulocytic and responds poorly to type 2-targeted biologics. Well-annotated serum lets these endotypes be studied as distinct populations rather than as treatment failures.
• Serum for serology, plasma for coagulation-sensitive work — use serum for IgE and protein immunoassays; the plasma sibling is appropriate for coagulation-sensitive analytes, cell-free nucleic acids and untargeted metabolomics.

Donor Stratification Available

• Severity: mild, moderate or severe asthma; treatment step and exacerbation history where recorded
• Blood eosinophil count and total IgE where recorded, to support type 2-high versus type 2-low endotype selection
• Allergic/atopic versus non-atopic asthma, with allergen sensitisation profile where available
• Treatment status: inhaled corticosteroid with or without long-acting bronchodilator, oral corticosteroid dependence, or biologic therapy (anti-IgE, anti-IL-5 pathway, anti-IL-4R, anti-TSLP)
• Comorbid atopic conditions: allergic rhinitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis
• Smoking status and age of onset (childhood versus adult onset)
• Matched healthy controls available, age- and sex-matched on request

Product Features

• Collected from clinically confirmed asthma donors
• Processed and frozen within 24 hours of collection
• Custom aliquot volumes available; volumes reported per lot
• Research Use Only (RUO)
• IRB-approved protocols with documented consent

De-identified Donor Data

• Diagnosis confirmation, with severity classification where available
• Age, sex assigned at birth, and race/ethnicity
• Donor-reported allergy, medication and infectious disease history
• Eosinophil count, IgE level and lung function values where recorded

Applications

• Total and allergen-specific IgE assay development and validation
• Type 2 endotype biomarker discovery and validation
• Serum cytokine and multiplex protein profiling
• Eosinophil activation marker research
• Biologic therapy response and non-response research
• Comparative studies of type 2-high versus type 2-low asthma populations
• Allergen sensitisation and atopic comorbidity research
• Therapeutic candidate screening and companion assay development for respiratory programmes

Other Asthma Specimen Types

• Asthma Plasma
• Asthma Whole Blood
• Asthma PBMC
• Asthma Leukopak
• Asthma Bulk Plasma
• Allergy Serum for atopic comparator cohorts

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Asthma serum is available in standard and custom volumes. For pricing, availability or a specific endotype or stratification request, email learnmore@sanguinebio.com; please also contact us for international orders or documentation requirements to ensure compatibility with your country’s regulations. To browse availability across all disease states, visit our human serum page.