Behcet’s Disease Whole Blood

Behçet’s Disease Whole Blood for Variable-Vessel Vasculitis Research

Fresh Behçet’s Disease Whole Blood is collected from IRB-consented donors with clinically confirmed Behçet’s disease and shipped same day for maximum viability. Behçet’s disease is a chronic, relapsing, immune-mediated variable-vessel vasculitis whose classification is genuinely debated between autoinflammatory and autoimmune disease, and is best described as autoinflammatory-leaning. It features a strong HLA-B51 association, marked neutrophil hyperactivity, and Th1/Th17 skewing. Whole blood preserves every cellular compartment together with plasma, making it well suited to neutrophil function work, immunophenotyping, and genotyping from a single draw.

Behçet’s Immunobiology and Why Whole Blood

• Variable-vessel vasculitis: inflammation can involve arteries and veins of any size, which sets Behçet’s apart from vasculitides defined by vessel calibre. Venous thrombosis, arterial involvement, and pulmonary artery aneurysm are recognized manifestations.
• Immune-mediated and autoinflammatory-leaning: features span both categories — episodic sterile inflammation, innate cell hyperactivity, and IL-1 pathway involvement on the autoinflammatory side; a strong HLA association and adaptive T cell skewing on the autoimmune side. No defining autoantibody has been established for Behçet’s disease.
• HLA-B51 and genetic risk: HLA-B*51 is the strongest known genetic association, with additional loci reported at IL10, IL23R-IL12RB2, and ERAP1. Whole blood yields high-quality genomic DNA for HLA typing and genotyping alongside cellular assays from the same specimen.
• Neutrophil hyperactivity: increased chemotaxis, oxidative burst, and neutrophil extracellular trap formation are central to lesion pathology and to the pathergy phenomenon. These assays require fresh, unseparated blood with granulocytes intact.
• Th1/Th17 skewing: elevated IFN-gamma, IL-17, IL-21, and TNF responses are consistent with the clinical utility of TNF inhibitors and, in certain manifestations, IL-1 or IL-17 pathway blockade.
• Single-draw versatility: supports whole-blood stimulation assays, flow cytometry without density-gradient loss of granulocytes, RNA stabilization for transcriptomics, and DNA extraction from one collection.

Donor Stratification Available

• Organ involvement: mucocutaneous (oral and genital ulcers), ocular (uveitis, retinal vasculitis), vascular (venous thrombosis, aneurysm), neuro-Behçet’s, gastrointestinal, or articular
• HLA-B51 status where documented
• Disease activity: active flare versus remission
• Treatment status: colchicine, corticosteroid, azathioprine or other conventional immunosuppressant, TNF inhibitor, apremilast, or treatment-naive
• Pathergy test result where documented
• Geographic ancestry, including donors from populations along the historical Silk Road where prevalence is highest
• Matched healthy controls available

Product Features

• Research Use Only (RUO)
• Fresh whole blood from clinically diagnosed Behçet’s disease donors
• Custom tubes and anticoagulants available (EDTA, sodium citrate, sodium heparin, ACD)
• Collected and shipped same-day for maximum freshness
• IRB-approved protocols and electronic informed consent
• Custom volumes available upon request

De-identified Donor Data

• Confirmed Behçet’s disease diagnosis by physician or specialist
• Demographic details: age, sex assigned at birth, race/ethnicity
• Organ involvement pattern and disease activity status where documented
• Medical history including current therapy, allergies, and infectious disease status

Applications

• Neutrophil function assays: chemotaxis, oxidative burst, and NET formation
• Whole-blood cytokine stimulation and immune activation profiling
• Immunophenotyping of granulocyte, monocyte, T cell, and NK populations
• HLA-B51 typing and genetic association studies
• Gene expression and transcriptomic analysis in flare versus remission
• IL-1, IL-17, and TNF pathway drug response and mechanism-of-action studies
• Inflammatory marker and cytokine profiling
• Biomarker discovery for disease activity and organ involvement

Other Behçet’s Disease Specimen Types

• Behcet’s Disease PBMC
• Behcet’s Disease Plasma
• Behcet’s Disease Serum

Compliance and Quality Assurance

• IRB-approved protocols and electronic informed consent
• HIPAA-compliant data management
• Rigorous donor screening and documentation

Ordering & Customization

Behçet’s disease whole blood is available in a range of standard and custom volumes. For pricing, current availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse other conditions and live stock status, visit our human whole blood page.