Celiac Disease Bulk Plasma

About Celiac Disease Bulk Plasma

Celiac Disease Bulk Plasma for Autoimmune and Gluten-Related Disease Research

Celiac Disease Bulk Plasma is collected from IRB-consented donors diagnosed with celiac disease using apheresis, with ACDA (Acid-Citrate-Dextrose Formula A) as the anticoagulant. Celiac disease is an autoimmune enteropathy in which dietary gluten peptides, presented in the context of HLA-DQ2 or HLA-DQ8, drive a T cell-mediated response against the small intestinal mucosa together with characteristic autoantibody production against tissue transglutaminase. This high-volume, disease-state plasma supports immunology, biomarker discovery, assay development and therapeutic discovery.

Gluten-Driven Autoimmunity and Why Bulk Plasma

• Celiac disease is genuinely autoimmune: the hallmark serological finding is IgA autoantibody against tissue transglutaminase 2 (tTG), accompanied in many patients by anti-endomysial and deamidated gliadin peptide antibodies.
• Susceptibility is tightly restricted by HLA class II. Nearly all patients carry HLA-DQ2 or HLA-DQ8, which present deamidated gluten peptides to CD4+ T cells and initiate the mucosal immune response.
• Gluten exposure and gluten-free dietary adherence directly modulate autoantibody titre, making treatment and diet status a critical variable when selecting donors.
• Bulk apheresis plasma yields the litre-scale volumes needed for antibody purification, reference and calibrator panel manufacture, and repeated-use control material — work that single-donor tubes cannot support.
• ACDA anticoagulation and apheresis collection give a consistent, high-volume matrix suited to immunoassay development and to proteomic and metabolomic discovery.
• Plasma is acellular. It supports autoantibody quantification, cytokine and mucosal damage marker immunoassay and multi-omic profiling, but not cell-based or immunophenotyping assays.

Donor Stratification Available

• Serological status: tTG-IgA positive versus normalised titre
• Gluten-free diet adherence: newly diagnosed and untreated, adherent, or non-adherent
• HLA-DQ2 or HLA-DQ8 genotype where documented
• Biopsy-confirmed diagnosis with documented histological grade where available
• Presence of associated autoimmune conditions such as type 1 diabetes or autoimmune thyroid disease
• Matched healthy controls available

Product Features

• High-volume plasma collected via apheresis
• Anticoagulated using ACDA
• Tested and confirmed negative for HIV, HBV, and HCV
• Available fresh with custom volumes upon request
• Research Use Only (RUO)
• IRB-approved informed consent and HIPAA-compliant handling

De-identified Donor Data

• Clinically confirmed diagnosis of celiac disease with diagnostic method
• Donor demographics: age, sex assigned at birth, race/ethnicity
• Clinical history and medication data available
• Serology results and dietary status where documented

Applications

• Anti-tissue transglutaminase and deamidated gliadin peptide immunoassay development
• Serological reference, calibrator and control panel manufacture
• Autoantibody purification and characterisation at scale
• Disease-specific biomarker discovery and validation
• Cytokine and inflammatory mediator profiling
• Intestinal permeability and mucosal damage marker research
• Proteomic and metabolomic profiling of gluten-related disease
• Therapeutic development and validation studies, including gluten-degrading enzyme and immune tolerance programmes

Other Celiac Disease Specimen Types

• Celiac Disease Plasma
• Celiac Disease Serum
• Celiac Disease Whole Blood
• Celiac Disease PBMC
• Celiac Disease Leukopak
• Celiac Disease CD4+ T Cells

Compliance and Quality Assurance

• Screened negative for HIV, HBV, and HCV
• IRB-approved collection with 21 CFR Part 11–compliant consent
• Standardized processing and cryopreservation protocols

Ordering & Customization

Celiac Disease Bulk Plasma is available in standard or custom volumes. For pricing, current availability, documentation or international shipping, please contact learnmore@sanguinebio.com. To browse donor cohorts across our full inventory, visit our human plasma page.