Cirrhosis Plasma

About Cirrhosis Plasma

Cirrhosis Plasma for Fibrotic Liver Disease Research

Cirrhosis Plasma is collected from IRB-consented donors clinically diagnosed with cirrhosis and processed within one day of collection to preserve key analytes such as cytokines, proteins, and metabolites. Cirrhosis is the advanced stage of chronic hepatic fibrosis: sustained liver injury drives extracellular matrix deposition, architectural distortion with regenerative nodules, and portal hypertension. This human plasma supports research on fibrosis staging, portal hypertension, hepatic synthetic function, and non-invasive biomarker development.

Cirrhosis Biology and Why Plasma

• Fibrogenesis: hepatic stellate cell activation and myofibroblast transformation drive collagen and matrix deposition. Plasma carries matrix turnover markers including PRO-C3, hyaluronic acid, and TIMP-1, alongside metalloproteinase activity.
• Portal hypertension: increased intrahepatic resistance combined with splanchnic vasodilation produces varices, ascites, and hypersplenism, with downstream changes in platelet count and circulating vasoactive mediators.
• Loss of synthetic and clearance function: falling albumin, prolonged coagulation times, and rising bilirubin underpin Child-Pugh and MELD scoring, making plasma a natural matrix for functional staging research.
• Rebalanced hemostasis: cirrhosis reduces synthesis of both procoagulant and anticoagulant factors, and citrated plasma is the standard specimen for coagulation factor, thrombin generation, and von Willebrand factor studies.
• Systemic inflammation and the gut-liver axis: bacterial translocation and endotoxemia elevate circulating cytokines and contribute to the immune dysfunction associated with decompensation.
• Acellular matrix: plasma suits proteomic, metabolomic, cell-free DNA, and immunoassay work on soluble analytes. Cell-based assays are supported by our cirrhosis PBMC, leukopak, and whole blood products.

Donor Stratification Available

• Etiology: chronic hepatitis B or C, alcohol-related liver disease, MASH/NAFLD-related, autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, or cryptogenic — autoimmune and cholestatic causes are one group among several, not the general case
• Child-Pugh class A, B, or C
• MELD or MELD-Na score band where documented
• Compensated versus decompensated disease
• Decompensation events: ascites, variceal bleeding, or hepatic encephalopathy
• Hepatocellular carcinoma status, and transplant waitlist or post-transplant status
• Antiviral treatment history and sustained virologic response status in viral etiologies
• Matched healthy controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed cirrhosis donors
• Processed within one day of collection
• Choice of anticoagulant (EDTA, sodium citrate, or heparin) on request
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified cirrhosis diagnosis with documented etiology
• Demographic data: age, sex assigned at birth, race/ethnicity
• Child-Pugh class and MELD score where available
• Donor-reported medications, allergies, and comorbidities
• Additional cirrhosis-specific metadata available on request

Applications

• Non-invasive fibrosis biomarker discovery and validation
• Matrix turnover and fibrogenesis marker panels
• Proteomic and metabolomic profiling across Child-Pugh and MELD strata
• Coagulation and hemostasis research in citrated plasma
• Cytokine and systemic inflammation profiling in decompensation
• Etiology-stratified comparisons across viral, alcohol-related, MASH, and cholestatic disease
• Cell-free DNA and extracellular vesicle studies
• Antifibrotic drug development and pharmacodynamic biomarker work

Other Cirrhosis Specimen Types

• Cirrhosis Serum
• Cirrhosis Whole Blood
• Cirrhosis PBMC
• Cirrhosis Leukopak

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Cirrhosis plasma is available in standard and custom volumes. For pricing, current availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse other conditions and live stock status, visit our human plasma page.