Depressive Disorder Plasma
Depressive Disorder Plasma is collected from IRB-consented donors with clinically confirmed depression or major depressive disorder. Suitable for soluble biomarker discovery, inflammatory marker profiling such as CRP and IL-6, HPA-axis hormone measurement, and plasma proteomics. Depression is not an autoimmune disease and no validated diagnostic blood biomarker exists; these samples are intended for exploratory research.
Depressive Disorder Plasma for Neuropsychiatric and Inflammation Research
Depressive Disorder Plasma is collected from IRB-consented adult donors with a clinically confirmed diagnosis of depression or major depressive disorder (MDD), and processed within one day of collection to preserve cytokines, proteins, hormones, and metabolites. Plasma is an acellular matrix, so this product supports soluble-analyte measurement rather than cell-based assays.
Depression Neurobiology and Why Plasma
Major depressive disorder is a neuropsychiatric condition. It is not an autoimmune disease, and no autoantibody or autoimmune mechanism defines it. Plasma is used to study circulating mediators that have been associated with depression and with antidepressant response.
- Monoamine signalling (serotonin, noradrenaline, dopamine) remains the pharmacological basis of most approved antidepressants, and plasma supports drug-exposure and metabolite measurement in that context
- Hypothalamic-pituitary-adrenal (HPA) axis regulation is a long-standing research focus; cortisol and ACTH are measurable in plasma, and altered cortisol dynamics have been reported in subsets of patients
- A well-documented literature reports modestly elevated inflammatory markers, including CRP, IL-6 and TNF-alpha, in a subset of people with depression. This is best treated as an association rather than an established cause
- Neurotrophic and metabolic mediators are frequently profiled, though circulating levels are sensitive to preanalytical handling and should be interpreted with matched controls
- There is no validated diagnostic blood biomarker for depression. Plasma is appropriate for hypothesis-generating discovery, assay development, and cohort stratification, not for diagnosis
- Unbiased proteomic and metabolomic workflows, multiplex immunoassays, and targeted ELISA all run directly on plasma
Donor Stratification Available
- Major depressive disorder versus persistent depressive disorder
- Treatment-naive donors versus donors currently on antidepressant therapy (SSRI, SNRI, or other class)
- Treatment-resistant depression, defined by inadequate response to prior adequate antidepressant trials
- Clinician-assessed severity, or standard rating-scale score where recorded
- Presence or absence of comorbid anxiety disorder, or comorbid cardiometabolic disease
- Matched healthy controls available
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed MDD donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
- Anticoagulant selection available on request to match your assay
De-identified Donor Data
- Verified MDD diagnosis
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Psychiatric treatment history where available
- Additional depression-specific metadata available on request
Applications
- Exploratory biomarker discovery in depression cohorts
- Inflammatory marker profiling, including CRP, IL-6 and TNF-alpha
- HPA-axis and stress-hormone measurement
- Plasma proteomics and untargeted metabolomics
- Immunoassay and multiplex panel development and validation
- Antidepressant pharmacokinetic and drug-exposure studies
- Treatment-response and treatment-resistance comparisons against matched controls
- Reference material for neuropsychiatric assay qualification
Other Depressive Disorder Specimen Types
- Depressive Disorder Serum
- Depressive Disorder Whole Blood
- Depressive Disorder PBMC
- Depressive Disorder Leukopak
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Depressive Disorder plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse plasma from other disease states and check live stock status, visit our human plasma page.
Protocols & Documentation
-
Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
-
Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
1 Answer
YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
1 Answer
YES – all our products are research use only (RUO).
1 Answer
You can find our full product catalog here.
1 Answer
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
1 Answer
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
1 Answer
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
1 Answer
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
1 Answer
YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
1 Answer
Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
1 Answer
YES – Unique donors can be specified and guaranteed based on your requirements.
1 Answer
For information about sample quality, please see: Quality and Compliance
1 Answer
YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.