Depressive Disorder Plasma

About Depressive Disorder Plasma

Depressive Disorder Plasma for Neuropsychiatric and Inflammation Research

Depressive Disorder Plasma is collected from IRB-consented adult donors with a clinically confirmed diagnosis of depression or major depressive disorder (MDD), and processed within one day of collection to preserve cytokines, proteins, hormones, and metabolites. Plasma is an acellular matrix, so this product supports soluble-analyte measurement rather than cell-based assays.

Depression Neurobiology and Why Plasma

Major depressive disorder is a neuropsychiatric condition. It is not an autoimmune disease, and no autoantibody or autoimmune mechanism defines it. Plasma is used to study circulating mediators that have been associated with depression and with antidepressant response.

• Monoamine signalling (serotonin, noradrenaline, dopamine) remains the pharmacological basis of most approved antidepressants, and plasma supports drug-exposure and metabolite measurement in that context
• Hypothalamic-pituitary-adrenal (HPA) axis regulation is a long-standing research focus; cortisol and ACTH are measurable in plasma, and altered cortisol dynamics have been reported in subsets of patients
• A well-documented literature reports modestly elevated inflammatory markers, including CRP, IL-6 and TNF-alpha, in a subset of people with depression. This is best treated as an association rather than an established cause
• Neurotrophic and metabolic mediators are frequently profiled, though circulating levels are sensitive to preanalytical handling and should be interpreted with matched controls
• There is no validated diagnostic blood biomarker for depression. Plasma is appropriate for hypothesis-generating discovery, assay development, and cohort stratification, not for diagnosis
• Unbiased proteomic and metabolomic workflows, multiplex immunoassays, and targeted ELISA all run directly on plasma

Donor Stratification Available

• Major depressive disorder versus persistent depressive disorder
• Treatment-naive donors versus donors currently on antidepressant therapy (SSRI, SNRI, or other class)
• Treatment-resistant depression, defined by inadequate response to prior adequate antidepressant trials
• Clinician-assessed severity, or standard rating-scale score where recorded
• Presence or absence of comorbid anxiety disorder, or comorbid cardiometabolic disease
• Matched healthy controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed MDD donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request
• Anticoagulant selection available on request to match your assay

De-identified Donor Data

• Verified MDD diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Psychiatric treatment history where available
• Additional depression-specific metadata available on request

Applications

• Exploratory biomarker discovery in depression cohorts
• Inflammatory marker profiling, including CRP, IL-6 and TNF-alpha
• HPA-axis and stress-hormone measurement
• Plasma proteomics and untargeted metabolomics
• Immunoassay and multiplex panel development and validation
• Antidepressant pharmacokinetic and drug-exposure studies
• Treatment-response and treatment-resistance comparisons against matched controls
• Reference material for neuropsychiatric assay qualification

Other Depressive Disorder Specimen Types

• Depressive Disorder Serum
• Depressive Disorder Whole Blood
• Depressive Disorder PBMC
• Depressive Disorder Leukopak

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Depressive Disorder plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse plasma from other disease states and check live stock status, visit our human plasma page.