Healthy Pediatrics Plasma
Healthy Pediatrics Plasma - Cryopreserved plasma from healthy pediatric volunteers collected under IRB-approved protocols with parental or guardian consent. Built for pediatric reference interval establishment, assay normal-range work, control arms for pediatric disease studies, and developmental biomarker research. Age-band, sex, and BMI percentile stratification available.
Healthy Pediatrics Plasma for Reference Range and Developmental Biology Research
Healthy Pediatrics Plasma is collected from healthy pediatric donors under IRB-approved protocols, with parental or guardian permission and age-appropriate assent where applicable. These are healthy volunteers, not patients, and no disease diagnosis is associated with this product. Samples are processed within one day of collection to preserve labile analytes such as cytokines, proteins, lipids, and metabolites, then aliquoted and cryopreserved. Research Use Only (RUO).
Pediatric Reference Biology and Why It Matters
- Children are not small adults at the analyte level. The immune system matures progressively through infancy and childhood, including a shift in the balance of naive and memory lymphocyte populations and maturation of immunoglobulin isotype levels as maternally derived antibody declines and endogenous production rises.
- Many plasma proteins follow developmental trajectories. Growth-associated analytes such as alkaline phosphatase vary substantially with skeletal growth and puberty, and hemostatic protein levels differ in neonates and infants relative to older children.
- Lipid and lipoprotein profiles change across childhood and shift again through puberty, and endocrine analytes change markedly with pubertal stage. Sex differences emerge and widen through adolescence.
- For these reasons, clinical and research reference intervals for pediatric specimens must be partitioned by age band and often by sex. Applying an adult range to a pediatric sample can misclassify a normal value as abnormal.
- The practical constraint is supply. Healthy pediatric blood is difficult to source: collection volumes are limited, consent requires parental or guardian permission alongside child assent, and healthy children are rarely phlebotomized outside a research protocol. Ethically consented, well-annotated healthy pediatric plasma is the scarce input, and that is the value of this product.
- Plasma is acellular and is appropriate for soluble protein, cytokine, lipid, and metabolite measurement rather than any cell-based assay.
Donor Stratification Available
- Age band: infant, toddler, young child, older child, and adolescent cohorts
- Narrow custom age windows on request for age-partitioned reference work
- Sex assigned at birth, with sex-partitioned cohorts available
- BMI percentile for age and sex
- Self-reported race/ethnicity for population-representative cohort design
- Medication-free status and absence of reported chronic conditions; vaccination status where documented
Product Features
- Research Use Only (RUO)
- Plasma collected from screened healthy pediatric volunteers
- Processed within one day of collection
- Cryopreserved for long-term stability, with standardized anticoagulant and processing workflow
- IRB-approved protocols with informed parental or guardian consent and age-appropriate child assent
- Small-volume and custom aliquot options appropriate to pediatric collection limits
De-identified Donor Data
- Confirmed healthy status at time of collection, with no reported chronic disease diagnosis
- Demographic data: age, sex assigned at birth, race/ethnicity
- Height, weight, and BMI percentile where available
- Donor-reported medications, allergies, and recent illness history
- Additional pediatric metadata available on request
Applications
- Establishing and verifying pediatric reference intervals, partitioned by age band and sex
- Assay normal-range establishment and transference studies for pediatric use
- Control arms for pediatric disease cohort studies
- Developmental biomarker research across age bands
- Characterization of age-dependent immune maturation using soluble immune analytes
- Developmental lipidomics, metabolomics, and plasma proteomics
- Baseline matrix for pediatric pharmacology and dose-finding research
- Healthy pediatric matrix for immunoassay development, validation, and lot qualification
Other Healthy Pediatric Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures, obtained from a parent or legal guardian
- Documentation support available for regulatory review
Ordering & Customization
Healthy Pediatrics Plasma is available in standard and custom volumes, including small-volume aliquots suited to pediatric collections. For pricing, availability, age-band-specific cohort requests, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse all matrices and donor cohorts, visit our human plasma page.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.