Healthy Pediatrics Serum
Normal serum from screened healthy paediatric donors collected under IRB-approved protocols with guardian consent and frozen within 24 hours. Reference material for age-appropriate reference intervals, paediatric assay validation and age-matched control arms. Available by age band, sex and pubertal stage where recorded.
Healthy Pediatric Serum for Reference Range and Pediatric Assay Research
Healthy Pediatrics Serum is collected from IRB-consented healthy paediatric donors with parental or guardian consent and age-appropriate assent, and processed and frozen within 24 hours of collection. These are not disease specimens: they are normal paediatric reference material for establishing age-appropriate baselines, validating assays intended for paediatric use, and serving as matched controls in paediatric disease studies.
Why Age-Matched Pediatric Serum Matters
Adult reference serum is not a valid substitute for paediatric material. Many circulating analytes have reference intervals that change substantially with age and pubertal development, so an assay calibrated or validated only on adult serum can misclassify a healthy child.
- Immune ontogeny — immunoglobulin isotypes mature on distinct trajectories, with IgG passing through a physiologic nadir in infancy and IgA rising latest, so paediatric immunology baselines cannot be inferred from adults.
- Growth and bone turnover — alkaline phosphatase and IGF-1 track skeletal growth and peak around the pubertal growth spurt, producing paediatric ranges that overlap poorly with adult ones.
- Endocrine transitions — thyroid, gonadal and adrenal axis analytes shift markedly with pubertal stage, making Tanner-stage or age-band matching essential in endocrinology research.
- Assay validation for paediatric indications — regulatory and clinical development programmes need normal paediatric matrix for accuracy, interference, linearity and reference-interval work in the intended population.
- Matrix for spike-recovery and calibration — normal paediatric serum provides a biologically appropriate background for recovery and parallelism experiments.
- Matched controls for paediatric disease cohorts — comparisons in paediatric autoimmune, genetic, oncology and infectious disease studies are only interpretable against age-matched normal serum.
Donor Stratification Available
- Age band: infant, toddler, young child, older child and adolescent cohorts
- Sex assigned at birth, with balanced male and female cohorts on request
- Pubertal or Tanner stage where recorded
- Race and ethnicity for demographically representative cohorts
- BMI percentile, fasting status and time of collection where recorded
- Absence of chronic disease and current medication confirmed at screening
- Matched healthy adult control serum available for cross-age comparison studies
Product Features
- Collected from screened healthy paediatric donors under parental or guardian consent
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- IRB-approved protocols with documented consent and age-appropriate assent
- Custom aliquot volumes available; volumes reported per lot
De-identified Donor Data
- Confirmed healthy status at screening, with no known chronic condition
- Age, sex assigned at birth, and race/ethnicity
- Donor- or guardian-reported medical history, medications and allergies
- Anthropometric and collection metadata where available
Applications
- Establishing and verifying paediatric reference intervals
- Assay validation and qualification for paediatric indications
- Matrix for calibration, spike-recovery and interference testing
- Age-matched control arms in paediatric disease biomarker studies
- Paediatric immune ontogeny and immunoglobulin profiling
- Growth, bone turnover and endocrine axis research
- Serum cytokine and multiplex protein panel normalisation
- Vaccine serology baseline and normal-range research
Other Healthy Pediatric Specimen Types
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Healthy paediatric serum is available in standard and custom volumes. For pricing, availability or a specific age-band or cohort request, email learnmore@sanguinebio.com; please also contact us for international orders or documentation requirements to ensure compatibility with your country’s regulations. To browse availability across all donor populations, visit our human serum page.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.