Hepatitis B Plasma

About Hepatitis B Plasma

Hepatitis B Plasma for Virology and Infectious Disease Research

Hepatitis B Plasma is collected from IRB-consented donors clinically diagnosed with hepatitis B virus (HBV) infection and processed within hours of collection to preserve viral nucleic acid, circulating viral antigens, cytokines, and metabolites. Custom aliquot volumes and anticoagulant types are available.

Why Plasma for Hepatitis B Research

HBV is a chronic viral infection, and the research question is the interaction between a persistent hepatotropic virus and the host immune response — not autoimmunity. Plasma is the standard matrix for HBV nucleic acid and antigen quantification, because it is collected with anticoagulant and separated without a clotting step, avoiding the analyte changes and cellular release that clotting introduces.

• Circulating viral markers in one matrix — HBV DNA, hepatitis B surface antigen (HBsAg), and hepatitis B e antigen (HBeAg) are all measurable in plasma, allowing viral load and antigen burden to be assessed together
• HBsAg is produced in vast excess — subviral particles greatly outnumber infectious virions, which is why quantitative HBsAg is a distinct readout from HBV DNA and why HBsAg loss defines functional cure
• Persistence is nuclear, not circulatory — covalently closed circular DNA (cccDNA) persists in hepatocyte nuclei and is not eliminated by nucleoside analogue therapy, so plasma markers are the practical non-invasive window on residual viral activity
• Disease phase drives interpretation — HBeAg-positive and HBeAg-negative chronic infection and chronic hepatitis differ in viral load, ALT, and immune activity; specifying phase is essential to cohort design
• Exhausted virus-specific T cell response — the functional impairment of HBV-specific T cells in chronic infection is reflected in circulating cytokine and chemokine profiles measurable in plasma
• Anticoagulant choice matters — EDTA plasma is the conventional matrix for viral nucleic acid quantification; alternative anticoagulants are available where downstream assays require them

Donor Stratification Available

• HBeAg status — HBeAg-positive versus HBeAg-negative infection
• Viral load and antigen level — HBV DNA and quantitative HBsAg reported per lot where measured
• Treatment status — untreated, on nucleoside/nucleotide analogue therapy, or previously treated
• Liver status — ALT level, fibrosis stage, or cirrhosis where recorded
• Co-infection — hepatitis D, hepatitis C, or HIV co-infection where documented; genotype where available
• Matched healthy controls available — demographically matched HBV-negative donors

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed Hepatitis B donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes and anticoagulant types available upon request

De-identified Donor Data

• Verified Hepatitis B diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Additional Hepatitis B-specific metadata, including serological and virological values, available on request

Applications

• HBV DNA quantification and viral kinetics research
• Quantitative HBsAg and HBeAg assay development and validation
• Serological assay and diagnostic panel development
• Antiviral and functional-cure candidate response research
• Cytokine, chemokine, and inflammation profiling in chronic infection
• Liver fibrosis and disease progression biomarker discovery
• Proteomic and metabolomic profiling across infection phases
• Reference and control material for infectious disease testing platforms

Other Hepatitis B Specimen Types

Matched material from the same HBV donor pool is available as hepatitis B serum, whole blood, PBMC, and leukopak. Larger volumes are available as hepatitis B bulk plasma.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Hepatitis B plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse the full specimen range and healthy-donor controls, see our human plasma collection.