Hypertension PBMC

About Hypertension PBMC

Hypertension PBMC for Cardiovascular Genomics and Vascular Inflammation Research

Hypertension PBMC samples are collected from IRB-consented donors clinically diagnosed with hypertension (high blood pressure) and processed under controlled conditions within 24 hours of collection. Hypertension itself is a vascular and metabolic disorder — driven by the renin-angiotensin-aldosterone system, sympathetic tone, renal sodium handling, endothelial dysfunction, and vascular remodelling — so these cryopreserved peripheral blood mononuclear cells are supplied for genomic, transcriptomic, and immune-mechanism work rather than as a primary diagnostic assay matrix for blood pressure.

What These Cells Are Used For

• Genotyping and genetic association work: PBMCs are a convenient, high-quality source of genomic DNA for candidate-gene and genome-wide studies of blood pressure regulation, including RAAS pathway and sodium-handling loci.
• Transcriptomics: bulk and single-cell RNA sequencing of circulating leukocytes from hypertensive donors, including comparisons across treatment status and comorbidity.
• Immune contribution to vascular inflammation: the role of T cells, monocytes, and macrophages in vascular and perivascular inflammation is an active area of experimental hypertension research; these donors support translational human work in that area. This is a research hypothesis under investigation, not established clinical diagnostics.
• Monocyte and T-cell phenotyping by flow cytometry, mass cytometry, or CITE-seq, with paired de-identified clinical metadata.
• Ex vivo stimulation and functional assays to compare leukocyte responses between hypertensive donors and matched normotensive controls.
• Epigenetics: DNA methylation and chromatin accessibility profiling in cardiometabolic cohorts.

Donor Stratification Available

• Essential (primary) versus secondary hypertension
• Treated versus untreated / treatment-naive donors
• Antihypertensive drug class: ACE inhibitor, angiotensin receptor blocker, thiazide or thiazide-like diuretic, calcium channel blocker, beta blocker, mineralocorticoid receptor antagonist, or combination therapy
• Resistant hypertension
• Comorbid chronic kidney disease, type 2 diabetes, obesity, or dyslipidaemia
• Established target-organ damage, including left ventricular hypertrophy, prior stroke, or coronary artery disease
• Matched healthy normotensive controls available

Product Features

• Research Use Only (RUO), cryopreserved hypertension PBMC samples
• Clinically confirmed hypertension donors
• Available in cell counts ranging from 5 million to 2 billion
• Processed within 24 hours of collection
• Preserved using CryoStor® CS10 freezing media
• IRB-approved protocols and electronic informed consent
• Screening (LeukoLot™) available prior to bulk orders

De-identified Donor Data

• Verified hypertension diagnosis
• Donor demographics: age, sex assigned at birth, race/ethnicity
• Current medications, including antihypertensive class
• Self-reported allergies and infectious disease history
• Additional hypertension-specific clinical data available on request

Applications

• Genomic DNA extraction and genotyping for blood pressure and cardiometabolic loci
• Bulk and single-cell transcriptomic profiling of circulating leukocytes
• Immunophenotyping of monocyte and T-cell subsets in hypertensive versus normotensive donors
• Research into the immune contribution to vascular and perivascular inflammation
• Epigenomic profiling, including DNA methylation and ATAC-seq
• Ex vivo stimulation and cytokine release assays
• Drug screening and target validation in cardiovascular programmes
• Proteomic profiling of leukocyte lysates

Other Hypertension Specimen Types

Hypertension donor material is also available as Hypertension Serum, Hypertension Plasma, Hypertension Whole Blood, and Hypertension Leukopak. For serum-based renin, aldosterone, and natriuretic peptide measurements, the serum product is the appropriate matrix.

Compliance and Quality Assurance

• IRB-approved collections and protocols
• 21 CFR Part 11-compliant e-consent
• HIPAA-compliant donor data protection

Ordering & Customization

Hypertension PBMC samples ship on dry ice in standard or custom aliquots. For pricing, international orders, or regulatory documentation, contact learnmore@sanguinebio.com. Browse all human PBMCs or request a custom disease-state collection.