Myeloproliferative Neoplasm (MPN) Bone Marrow Mononuclear Cells

Myeloproliferative Neoplasm (MPN) Bone Marrow Mononuclear Cells for Hematology Research

Our Myeloproliferative Neoplasm (MPN) Bone Marrow Mononuclear Cells is a hematopoietic tissue sample isolated by density-gradient separation from bone marrow aspirate, capturing the full spectrum of marrow-resident hematopoietic stem, progenitor, and precursor cells that peripheral blood samples do not contain. Samples are sourced from IRB-consented donors clinically diagnosed with an MPN, a group of clonal hematopoietic stem cell disorders driving overproduction of mature blood cells.

MPN Biology and Why Bone Marrow

• Myeloproliferative neoplasms – including polycythemia vera, essential thrombocythemia, and primary myelofibrosis – arise from clonal hematopoietic stem cells within the bone marrow.
• Marrow morphology, including cellularity, megakaryocyte atypia, and reticulin/collagen fibrosis grading, is central to WHO diagnostic criteria and to distinguishing between MPN subtypes, information that peripheral blood alone cannot provide.
• Driver mutations in JAK2, CALR, or MPL are present in the great majority of MPN cases and are assessed alongside marrow morphology for diagnosis and prognostication.
• JAK inhibitor therapy (e.g. ruxolitinib) has become central to MPN management, and marrow-derived material supports pharmacodynamic and resistance research.
• Marrow fibrosis progression and stem cell clonal dynamics are active areas of research into disease evolution and transformation risk.

Donor Stratification Available

• MPN subtype: polycythemia vera, essential thrombocythemia, or primary myelofibrosis
• Driver mutation status: JAK2, CALR, or MPL
• Marrow fibrosis grade where documented
• Treatment history, including JAK inhibitor exposure
• Age band and sex assigned at birth
• Matched healthy bone marrow controls available

Product Features

• Isolated from clinically confirmed MPN donor bone marrow aspirate
• Density-gradient purified and cryopreserved
• Research Use Only (RUO)
• IRB-approved protocols with documented consent
• Standard and custom cell quantities available

De-identified Donor Data

• MPN diagnosis confirmation, subtype, and driver mutation status where documented
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• Treatment history where documented
• Additional MPN-specific metadata available on request

Applications

• JAK2, CALR, and MPL driver mutation studies
• JAK inhibitor pharmacodynamic and resistance research
• Marrow fibrosis progression and stem cell clonal dynamics studies
• MPN subtype classification and biomarker research
• Disease transformation risk studies

Other Specimen Types

For matched marrow-derived material across conditions, see our human bone marrow mononuclear cells collection.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

MPN bone marrow mononuclear cells are available in standard and custom cell quantities. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations.