Obesity Serum

About Obesity Serum

Obesity Serum for Metabolic Disease and Metabolic Inflammation Research

Our Obesity Serum is sourced from IRB-consented donors clinically diagnosed with obesity. Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for metabolic, endocrine and cardiometabolic research. Obesity is a chronic metabolic condition in which excess and dysfunctional adipose tissue alters systemic endocrine and inflammatory signalling — changes that are directly measurable in circulation.

Adipose Endocrine Signalling and Metabolic Inflammation

• Adipose tissue is an endocrine organ. With expansion it alters secretion of adipokines including leptin and adiponectin, and these shifts are reflected in circulating concentrations measurable by serum immunoassay.
• Expanded adipose tissue in obesity is associated with low-grade chronic inflammation and macrophage infiltration, with corresponding changes in circulating inflammatory mediators such as CRP, IL-6 and TNF-related analytes. This is metabolic inflammation, not autoimmunity.
• Insulin resistance commonly accompanies obesity, and serum supports fasting glucose, insulin and derived insulin-sensitivity index work alongside HbA1c-adjacent metabolic characterisation.
• Dyslipidaemia in obesity typically involves raised triglycerides and altered lipoprotein composition, making serum the standard matrix for lipid panels and lipidomic profiling.
• Serum is acellular and well suited to hormone and adipokine immunoassay, clinical chemistry, proteomics, metabolomics and lipidomics; no cell-based assays are performed on this matrix.
• Incretin and appetite-regulatory biology is a major therapeutic focus in obesity, and characterised donor serum supports assay development and biomarker validation in that space.

Donor Stratification Available

• BMI class as documented (class I, class II or class III obesity)
• Presence or absence of type 2 diabetes or documented prediabetes
• Metabolic syndrome component status where documented
• Metabolic dysfunction-associated fatty liver disease and other documented comorbidities
• Treatment status: incretin-based therapy, other weight management pharmacotherapy, prior bariatric surgery, or untreated
• Matched healthy controls available

Product Features

• Collected from clinically confirmed obesity donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• IRB-approved protocols with documented consent
• Fasting collections and custom aliquot volumes available on request

De-identified Donor Data

• Diagnosis confirmation with BMI where available
• Age, sex assigned at birth, and ethnicity
• Donor-reported medical history and comorbidities
• Concurrent medications, including weight management and glucose-lowering therapy where reported

Applications

• Adipokine profiling, including leptin and adiponectin immunoassay work
• Lipid panel, lipoprotein and lipidomic analysis
• Insulin resistance and glucose metabolism biomarker research
• Inflammatory mediator profiling in metabolic inflammation
• Serum proteomic and metabolomic discovery studies
• Cardiometabolic risk biomarker discovery and validation
• Incretin and metabolic therapeutic candidate screening and pharmacodynamic assay development
• Clinical chemistry assay development across an elevated-BMI reference population

Other Obesity Specimen Types

• Obesity Plasma
• Obesity Bulk Plasma
• Obesity Whole Blood
• Obesity PBMC
• Obesity Leukopak

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Obesity serum is available in standard and custom volumes. For pricing, current availability, international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse donor cohorts across our full inventory, visit our human serum page.