Sleep Apnea Plasma
Plasma from clinically confirmed sleep apnea donors, processed under standardised SOPs. Sleep apnea drives cardiometabolic risk through intermittent hypoxia, oxidative stress and sympathetic activation rather than autoimmunity. Supports endothelial dysfunction, oxidative stress, inflammation and metabolomic research against a quantified apnea-hypopnea index. Stratifiable by severity, apnea type and CPAP status.
Sleep Apnea Plasma for Intermittent Hypoxia and Cardiometabolic Research
Sleep Apnea Plasma is collected from IRB-consented donors diagnosed with sleep apnea and processed under rigorous, standardised conditions. Obstructive sleep apnea is not an autoimmune or primary inflammatory disease. Its mechanism is mechanical and metabolic: repetitive upper-airway collapse during sleep produces cycles of hypoxia and reoxygenation together with sleep fragmentation, and it is those cycles that drive oxidative stress, sympathetic activation, endothelial dysfunction and insulin resistance. Plasma is the matrix in which those downstream consequences are measured.
Why Plasma for Sleep Apnea
Intermittent hypoxia is best understood as a systemic stressor. What distinguishes sleep apnea research is that the severity of that stressor is precisely quantified by polysomnography, so plasma analytes can be regressed against an objective physiological exposure measure.
- Quantified hypoxic burden — the apnea-hypopnea index, oxygen desaturation index and nadir oxygen saturation give a graded exposure variable, allowing dose-response relationships with circulating markers rather than simple case-control comparison.
- Endothelial dysfunction markers — soluble adhesion molecules such as ICAM-1 and VCAM-1 and other endothelial activation proteins are studied as the link between nocturnal hypoxia and daytime vascular risk.
- Systemic inflammation without autoimmunity — IL-6, TNF-alpha and CRP are elevated in moderate-to-severe disease as a consequence of hypoxic and sympathetic stress, not of self-directed immunity.
- Oxidative stress chemistry — hypoxia-reoxygenation cycling generates reactive oxygen species, and the resulting lipid and protein oxidation products are labile analytes that require prompt, standardised plasma processing.
- Insulin resistance and metabolic coupling — sleep apnea is independently associated with impaired glucose regulation and dyslipidaemia, and plasma supports metabolomic and lipidomic profiling of that link.
- Anticoagulated matrix is the right choice — for coagulation-sensitive proteins, cell-free DNA and untargeted metabolomics, plasma avoids the platelet-release and clotting-cascade artefacts that serum introduces.
Donor Stratification Available
- Severity category by apnea-hypopnea index: mild, moderate or severe as recorded on the diagnostic study
- Oxygen desaturation index and nadir oxygen saturation where recorded
- Apnea type: predominantly obstructive, central, or mixed
- Treatment status: untreated, on CPAP or other positive airway pressure with adherence data where available, oral appliance, or post-surgical
- BMI and obesity category, and comorbid hypertension, type 2 diabetes, atrial fibrillation or heart failure
- Daytime sleepiness score and diagnostic method (in-laboratory polysomnography versus home sleep apnea test) where recorded
- Matched healthy controls available, age-, sex- and BMI-matched on request
Product Features
- Plasma isolated from clinically confirmed sleep apnea donors
- Rigorous donor screening and sample quality checks
- Standardised collection and processing SOPs with controlled time to freeze
- Anticoagulant of choice (EDTA, sodium citrate, heparin) available on request
- Suitable for soluble-analyte applications including ELISA, multiplex immunoassay, mass spectrometry and cell-free nucleic acid work
- Custom aliquot volumes available; volumes reported per lot
- Research Use Only (RUO)
De-identified Donor Data
- Age, sex, race/ethnicity, medications, diagnosis method, and disease severity or stage
- Apnea-hypopnea index and oximetry parameters where recorded
- Treatment status and adherence where available
- Optional: comorbidities, laboratory values, and clinical history
Applications
- Endothelial dysfunction and vascular activation marker research
- Oxidative stress and lipid peroxidation profiling
- Cytokine and systemic inflammation profiling against graded hypoxic burden
- Metabolomics and lipidomics of insulin resistance and dyslipidaemia
- Proteomic and multiplex panel development
- Cardiovascular and cardiometabolic risk biomarker discovery
- CPAP treatment response and reversibility research
- Therapeutic development and screening for sleep-disordered breathing and its sequelae
Other Sleep Apnea Specimen Types
- Sleep Apnea Serum
- Sleep Apnea Whole Blood
- Sleep Apnea PBMC — for cellular and immunophenotyping work
- Sleep Apnea Leukopak
- Sleep Apnea Bulk Plasma
Compliance and Quality Assurance
- IRB-approved protocols and informed donor consent
- HIPAA-compliant donor data handling
- Standardised collection and processing SOPs
Ordering & Customization
Sleep apnea plasma is available in both standard and custom volumes to meet your research needs. For pricing, availability or a specific stratification request, email learnmore@sanguinebio.com. International Orders: for international shipments or country-specific documentation requirements, please contact us at the same address to ensure compliance with your local regulations. To browse availability across all disease states, visit our human plasma page.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.