Thyroid Eye Disease Plasma
Powered by BiozAbout:Thyroid Eye Disease Plasma is collected from consented donors with clinically confirmed TED, a Graves'-associated autoimmune orbital disease involving TSHR and IGF-1R signalling in orbital fibroblasts. Suitable for TSHR autoantibody and thyroid-stimulating immunoglobulin measurement, cytokine profiling, and disease-activity biomarker research. Available stratified by active versus fibrotic phase and treatment status, with matched healthy controls.
About Thyroid Eye Disease Plasma
Thyroid Eye Disease Plasma for Autoimmune Orbital Disease Research
Thyroid Eye Disease Plasma is collected from IRB-consented donors clinically diagnosed with thyroid eye disease (TED) and processed within one day of collection to preserve cytokines, autoantibodies, proteins and metabolites. Plasma is acellular, so this product is intended for soluble-analyte measurement rather than cell-based assays.
TED Autoimmunity and Why Plasma
Thyroid eye disease is an autoimmune orbital condition, in the great majority of cases occurring in association with Graves’ disease. The orbit, not the thyroid, is the site of the pathology.
- Stimulating autoantibodies against the thyrotropin receptor (TSHR), the same autoantibodies that cause Graves’ hyperthyroidism, are central to the disease and are detectable in circulation
- Orbital fibroblasts express TSHR and IGF-1R, and functional crosstalk between these receptors is the mechanistic basis for IGF-1R-directed therapy in TED
- Activated orbital fibroblasts secrete hyaluronan and a subset differentiate into adipocytes, expanding orbital soft tissue volume and producing proptosis and, in severe cases, optic neuropathy
- An active inflammatory phase precedes a stable fibrotic phase, and clinical activity scoring is used to distinguish them; treatment strategy differs between the two
- TSHR autoantibody levels, IGF-1 and inflammatory cytokines are all measurable in plasma, supporting non-invasive activity and treatment-response research without orbital biopsy
- Plasma supports autoantibody immunoassays, multiplex cytokine panels, proteomics and metabolomics from a single acellular sample
Donor Stratification Available
- Active inflammatory phase versus stable or fibrotic phase
- Clinical activity or severity grade where documented
- TSHR autoantibody status and titre where available
- Underlying thyroid status: hyperthyroid, euthyroid on treatment, or hypothyroid post-treatment
- Treatment status: treatment-naive, on corticosteroids, on IGF-1R-directed biologic therapy, or post-orbital surgery or radiotherapy
- Smoking status, an established risk factor for progression
- Matched healthy controls available
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed Thyroid Eye Disease donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
- Anticoagulant selection available on request to match your assay
De-identified Donor Data
- Verified Thyroid Eye Disease diagnosis
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Thyroid function and autoantibody results where available
- Additional thyroid eye disease-specific metadata available
Applications
- TSHR autoantibody and thyroid-stimulating immunoglobulin quantification
- IGF-1 and IGF-1R pathway soluble marker measurement
- Inflammatory cytokine and chemokine profiling
- Disease activity biomarker discovery and validation
- Fibrosis and extracellular matrix turnover marker measurement
- Plasma proteomics and metabolomics in orbital autoimmune disease
- Biologic therapy pharmacodynamic and treatment-response research
- Autoantibody immunoassay development against matched controls
Other Thyroid Eye Disease Specimen Types
- Thyroid Eye Disease Serum
- Thyroid Eye Disease Whole Blood
- Thyroid Eye Disease PBMC
- Graves’ Disease Serum
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Thyroid Eye Disease plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse plasma from other disease states and check live stock status, visit our human plasma page.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Plasma
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Plasma are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
-
Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
-
Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
Ask a Question
Pair with a Healthy Control
Match your Thyroid Eye Disease Plasma with normal donor samples for comparison
Healthy Plasma
206 In Stock View InventoryNeed a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.