Atopic Dermatitis Serum
Powered by BiozAbout:Atopic Dermatitis Serum — human serum from IRB-consented donors with clinically confirmed atopic dermatitis, processed and frozen within 24 hours of collection. Serum is the reference matrix for total and allergen-specific IgE and for CCL17/TARC, the best-replicated circulating severity biomarker in this disease. Donors can be stratified by EASI or SCORAD severity, IgE level, eosinophil count and biologic treatment status.
About Atopic Dermatitis Serum
Human Atopic Dermatitis Serum for Type 2 Inflammation and IgE Research
Our Atopic Dermatitis Serum is sourced from IRB-consented donors clinically diagnosed with atopic dermatitis, a chronic form of eczema. Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for dermatology and allergy research. Atopic dermatitis is an allergic, type 2-skewed inflammatory skin disease driven by the interaction of epidermal barrier dysfunction with Th2 cytokine signalling, rather than by autoantibodies against self.
Why Serum for Atopic Dermatitis Research
- Serum is the reference matrix for total IgE and for quantitative allergen-specific IgE. Elevated total IgE and broad polysensitisation are hallmarks of the extrinsic atopic dermatitis phenotype, and the clinical assays and thresholds were established in serum.
- CCL17 (TARC) is the most consistently replicated circulating biomarker of atopic dermatitis severity, and the published correlations with EASI and SCORAD were generated in serum — making serum the right matrix for comparability with that literature.
- Lactate dehydrogenase in serum has a long-standing reported association with atopic dermatitis severity and is measurable on standard clinical chemistry platforms alongside inflammatory markers.
- Eosinophil-derived proteins and periostin, an IL-13-inducible matricellular protein, are studied as severity and type 2 activity markers and are conventionally assayed in serum.
- Serum contains no anticoagulant, avoiding citrate or EDTA interference on the immunoassay and mass spectrometry platforms used for IgE quantification and for dermatology biomarker panels.
- Serum drawn alongside a skin punch biopsy from the same donor allows circulating type 2 activity to be related directly to lesional barrier and inflammatory biology.
Donor Stratification Available
- Disease severity by EASI, SCORAD or Investigator Global Assessment where recorded
- Total IgE level and blood eosinophil count where available
- Treatment status: topical-only, biologic-naive, on dupilumab or other type 2 biologic, on JAK inhibitor, on systemic immunosuppressant, or in washout
- Atopic comorbidity: asthma, allergic rhinitis, food allergy, or atopic dermatitis alone
- Age group, including paediatric and adult donors
- Disease duration and age at onset where reported
- Matched healthy controls available
Product Features
- Collected from clinically confirmed atopic dermatitis donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
- High-IgE and severity-selected donors available on request
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and race/ethnicity
- Donor-reported allergy and infectious disease history
- Disease severity and treatment history where available
- Explore our Atopic Dermatitis Donor Network
Applications
- Total and allergen-specific IgE measurement and assay development
- CCL17/TARC and type 2 chemokine biomarker research
- Serum cytokine and protein profiling of type 2 inflammation
- Periostin and eosinophil-derived protein measurement
- Biomarker discovery and validation for disease severity and treatment response
- Proteomic comparison of atopic dermatitis against psoriasis and other inflammatory skin disease
- Diagnostic and companion assay development using disease-state serum as a clinically relevant matrix
- Therapeutic candidate screening and target validation in type 2 inflammatory disease
Other Atopic Dermatitis Specimen Types
- Atopic Dermatitis Plasma
- Atopic Dermatitis Whole Blood
- Atopic Dermatitis PBMC
- Atopic Dermatitis Leukopak
- Atopic Dermatitis Skin Punch Biopsy
- Atopic Dermatitis Bulk Plasma
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Atopic dermatitis serum is available in standard and custom volumes. For pricing, availability, or to discuss a severity-stratified cohort, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse serum across all disease states and healthy donors, visit our human serum page.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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100 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.