Celiac Disease Plasma

About Celiac Disease Plasma

Celiac Disease Plasma for Gluten-Driven Autoimmunity Research

Celiac Disease Plasma is collected from IRB-consented donors clinically diagnosed with celiac disease and processed within hours of collection to preserve cytokines, proteins and metabolites. Celiac disease is a genuine autoimmune condition with an unusual feature: the driving antigen is dietary. Gluten peptides are modified by the host enzyme transglutaminase 2, presented by HLA-DQ2 or HLA-DQ8, and drive both a T-cell response against gluten and an autoantibody response against transglutaminase 2 itself. Bulk plasma is also available.

Why Plasma for Celiac Disease

Serology defines the diagnosis, but plasma is where the dynamic, mechanism-level readouts live — the cytokines, metabolites and barrier markers that change with gluten exposure and dietary adherence.

• Gluten challenge cytokine kinetics — one of the most striking findings in celiac immunology is that a systemic cytokine response, notably IL-2, is detectable in blood within hours of gluten ingestion in treated patients, giving a functional readout of gluten-reactive T cells that plasma is well suited to capture.
• Intestinal barrier and enterocyte damage — circulating markers of enterocyte injury and permeability are studied as non-invasive alternatives to repeat biopsy for monitoring mucosal recovery.
• Metabolomic consequences of villous atrophy — malabsorption alters circulating micronutrients, lipids and amino acids; untargeted metabolomics performs better in anticoagulated plasma than in serum, where clotting and platelet release distort the metabolite profile.
• Dietary adherence biology — because the only established treatment is gluten withdrawal, plasma from donors with documented adherence versus ongoing exposure lets treated and actively triggered states be compared directly.
• HLA-restricted mechanism — nearly all celiac patients carry HLA-DQ2 or DQ8, so plasma studies gain considerable power when paired with genotype and with the PBMC or T-cell products for antigen-specific work.
• Plasma-specific analytes — cell-free DNA, complement components and coagulation-sensitive proteins require anticoagulated plasma rather than serum.

Donor Stratification Available

• Anti-transglutaminase 2 IgA serostatus and titre category where reported, and anti-deamidated gliadin peptide status where available
• HLA-DQ2 and HLA-DQ8 genotype where available
• Biopsy confirmation and Marsh grade where recorded
• Dietary status: newly diagnosed and gluten-exposed, versus established gluten-free diet with duration and documented adherence
• Presentation: classical gastrointestinal, non-classical or extraintestinal, or refractory celiac disease
• Associated autoimmune conditions: type 1 diabetes, autoimmune thyroid disease, dermatitis herpetiformis
• Matched healthy controls available, age- and sex-matched on request

Product Features

• Research Use Only (RUO)
• Celiac disease plasma collected from clinically confirmed donors
• Processed within one day of collection
• Anticoagulant of choice (EDTA, sodium citrate, heparin) available on request
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request; volumes reported per lot

De-identified Donor Data

• Verified celiac disease diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies and comorbidities
• Serology, biopsy findings and dietary status where available
• Additional celiac disease-specific metadata available on request

Applications

• Cytokine profiling and gluten-response biomarker research
• Non-invasive markers of mucosal healing and intestinal permeability
• Untargeted and targeted metabolomics of malabsorption
• Proteomic and multiplex immunoassay panel development
• Dietary adherence monitoring biomarker discovery
• Nutrient deficiency and micronutrient status research
• Drug development for non-dietary celiac therapies, including transglutaminase 2 inhibition and tolerance induction
• Cell-free DNA and complement analyte studies

Other Celiac Disease Specimen Types

• Celiac Disease Serum — the preferred matrix for tTG-IgA and endomysial antibody serology
• Celiac Disease Whole Blood
• Celiac Disease PBMC
• Celiac Disease Leukopak
• Celiac Disease CD4+ T Cells
• Celiac Disease Bulk Plasma

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Celiac disease plasma is available in standard and custom volumes. For pricing, availability or a specific stratification request, email learnmore@sanguinebio.com; please also contact us for international orders or documentation requirements to ensure compatibility with your country’s regulations. To browse availability across all disease states, visit our human plasma page.