Cytomegalovirus Whole Blood
Cytomegalovirus Whole Blood from donors with documented CMV infection or seropositivity, shipped same-day. Valuable for viral load quantification, antigen-specific T-cell assays against pp65 and IE-1, adaptive NK-cell immunophenotyping, latency and reactivation studies, and antiviral research. Stratification by infection stage, serostatus, and immune status; matched healthy and CMV-seronegative controls available.
Cytomegalovirus Whole Blood for Infectious Disease and Viral Immunology Research
Fresh Cytomegalovirus Whole Blood is collected from IRB-consented donors with documented cytomegalovirus (CMV) infection or CMV seropositivity, and shipped same-day to preserve cell viability, viral nucleic acid, and RNA integrity. CMV is a betaherpesvirus that establishes lifelong latency after primary infection, so this is an infectious disease product: the immune features it supports are the host response to a persistent virus, not autoimmunity.
CMV Biology and Why Whole Blood
- CMV establishes lifelong latency after primary infection, with the myeloid lineage – CD34+ progenitors and monocytes – serving as the principal latent reservoir, and reactivation occurring on differentiation or immune suppression.
- Primary infection is usually subclinical in immunocompetent hosts but causes significant disease in transplant recipients, people with advanced HIV, and congenitally infected infants, making CMV a major target for antiviral and vaccine development.
- CMV drives an unusually large and durable adaptive response: CD8+ T-cell memory inflation can occupy a substantial fraction of the circulating T-cell repertoire in seropositive donors, and CMV-specific responses are commonly measured against pp65 and IE-1 antigens.
- CMV seropositivity is associated with expansion of adaptive or memory-like NK cells characterised by NKG2C expression and altered signalling-molecule profiles, an important consideration when sourcing donors for NK-cell work.
- Viral DNA in whole blood is the standard analyte for viral load quantification by real-time PCR, and whole blood also retains the latently infected myeloid compartment needed for reservoir and reactivation studies.
- Whole blood preserves leukocytes together with the plasma compartment, supporting parallel virological, serological, transcriptomic, and cellular immunology readouts from a single specimen.
Donor Stratification Available
- Infection stage: latent seropositive versus documented active infection or reactivation
- Serostatus detail: CMV IgG positive, IgM positive, or IgG avidity results where available
- Immune status: immunocompetent versus immunosuppressed, transplant recipient, or immunodeficient
- Antiviral treatment status, including ganciclovir/valganciclovir or letermovir exposure
- Co-infection status, including EBV and HIV serology where documented
- Age band, sex, and HLA type where typing is available
- Matched healthy controls available, including CMV-seronegative donors
Product Features
- Fresh whole blood from donors with documented CMV infection or seropositivity
- Custom tubes and anticoagulants available, including RNA-stabilising collection tubes
- Collected and shipped same-day for maximum freshness
- Standard and custom volumes
- IRB-approved protocols and electronic informed consent
- Research Use Only (RUO)
De-identified Donor Data
- Confirmed cytomegalovirus infection or seropositivity
- Demographic details: age, sex assigned at birth, ethnicity
- Medical history including allergies and infectious disease status
- Serology results, antiviral treatment, and immune status where documented
- Additional CMV-specific metadata available on request
Applications
- CMV viral load quantification and PCR assay development or validation
- Immunophenotyping of CMV-associated T-cell and adaptive NK-cell compartments by flow cytometry
- Antigen-specific T-cell assays against pp65 and IE-1, including ELISpot and intracellular cytokine staining
- Latency and reactivation studies using the myeloid reservoir
- Host transcriptomic response profiling in stabilised whole blood
- Serological assay development, including IgG, IgM, and avidity testing in the paired plasma fraction
- Antiviral drug susceptibility and resistance-mutation research
- Donor screening support for CMV-matched or CMV-naive cell therapy and NK-cell research programmes
Other Cytomegalovirus Specimen Types
Compliance and Quality Assurance
- IRB-approved protocols and electronic informed consent
- 21 CFR Part 11-compliant e-consent
- HIPAA-compliant data management
Ordering & Customization
Cytomegalovirus whole blood is available in a range of standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human whole blood page.
Whole Blood
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Whole Blood cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.