Cytomegalovirus Whole Blood

About Cytomegalovirus Whole Blood

Cytomegalovirus Whole Blood for Infectious Disease and Viral Immunology Research

Fresh Cytomegalovirus Whole Blood is collected from IRB-consented donors with documented cytomegalovirus (CMV) infection or CMV seropositivity, and shipped same-day to preserve cell viability, viral nucleic acid, and RNA integrity. CMV is a betaherpesvirus that establishes lifelong latency after primary infection, so this is an infectious disease product: the immune features it supports are the host response to a persistent virus, not autoimmunity.

CMV Biology and Why Whole Blood

• CMV establishes lifelong latency after primary infection, with the myeloid lineage – CD34+ progenitors and monocytes – serving as the principal latent reservoir, and reactivation occurring on differentiation or immune suppression.
• Primary infection is usually subclinical in immunocompetent hosts but causes significant disease in transplant recipients, people with advanced HIV, and congenitally infected infants, making CMV a major target for antiviral and vaccine development.
• CMV drives an unusually large and durable adaptive response: CD8+ T-cell memory inflation can occupy a substantial fraction of the circulating T-cell repertoire in seropositive donors, and CMV-specific responses are commonly measured against pp65 and IE-1 antigens.
• CMV seropositivity is associated with expansion of adaptive or memory-like NK cells characterised by NKG2C expression and altered signalling-molecule profiles, an important consideration when sourcing donors for NK-cell work.
• Viral DNA in whole blood is the standard analyte for viral load quantification by real-time PCR, and whole blood also retains the latently infected myeloid compartment needed for reservoir and reactivation studies.
• Whole blood preserves leukocytes together with the plasma compartment, supporting parallel virological, serological, transcriptomic, and cellular immunology readouts from a single specimen.

Donor Stratification Available

• Infection stage: latent seropositive versus documented active infection or reactivation
• Serostatus detail: CMV IgG positive, IgM positive, or IgG avidity results where available
• Immune status: immunocompetent versus immunosuppressed, transplant recipient, or immunodeficient
• Antiviral treatment status, including ganciclovir/valganciclovir or letermovir exposure
• Co-infection status, including EBV and HIV serology where documented
• Age band, sex, and HLA type where typing is available
• Matched healthy controls available, including CMV-seronegative donors

Product Features

• Fresh whole blood from donors with documented CMV infection or seropositivity
• Custom tubes and anticoagulants available, including RNA-stabilising collection tubes
• Collected and shipped same-day for maximum freshness
• Standard and custom volumes
• IRB-approved protocols and electronic informed consent
• Research Use Only (RUO)

De-identified Donor Data

• Confirmed cytomegalovirus infection or seropositivity
• Demographic details: age, sex assigned at birth, ethnicity
• Medical history including allergies and infectious disease status
• Serology results, antiviral treatment, and immune status where documented
• Additional CMV-specific metadata available on request

Applications

• CMV viral load quantification and PCR assay development or validation
• Immunophenotyping of CMV-associated T-cell and adaptive NK-cell compartments by flow cytometry
• Antigen-specific T-cell assays against pp65 and IE-1, including ELISpot and intracellular cytokine staining
• Latency and reactivation studies using the myeloid reservoir
• Host transcriptomic response profiling in stabilised whole blood
• Serological assay development, including IgG, IgM, and avidity testing in the paired plasma fraction
• Antiviral drug susceptibility and resistance-mutation research
• Donor screening support for CMV-matched or CMV-naive cell therapy and NK-cell research programmes

Other Cytomegalovirus Specimen Types

• Cytomegalovirus Plasma
• Cytomegalovirus Serum
• Cytomegalovirus PBMC

Compliance and Quality Assurance

• IRB-approved protocols and electronic informed consent
• 21 CFR Part 11-compliant e-consent
• HIPAA-compliant data management

Ordering & Customization

Cytomegalovirus whole blood is available in a range of standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare donor availability across conditions, visit our human whole blood page.