Discoid Lupus Erythematosus Serum

About Discoid Lupus Erythematosus Serum

Human Discoid Lupus Erythematosus Serum for Cutaneous Lupus Research

Our Discoid Lupus Erythematosus Serum is sourced from IRB-consented donors clinically diagnosed with discoid lupus erythematosus (DLE). Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for cytokine profiling, interferon-related analyte work, and serological studies. Research Use Only (RUO).

Cutaneous Lupus Biology and Why Serum

• Discoid lupus erythematosus is the most common form of chronic cutaneous lupus erythematosus. It is a skin-limited autoimmune disease, and most people with DLE do not have systemic lupus erythematosus. DLE should not be treated as an SLE surrogate.
• Lesions are well-demarcated, scaly, and often scarring, with follicular plugging and dyspigmentation; scalp involvement can produce scarring alopecia. Ultraviolet exposure is a recognized trigger.
• Histologically the disease is an interface dermatitis with a lymphocytic infiltrate at the dermoepidermal junction and around adnexal structures, indicating a cell-mediated, skin-directed autoimmune process.
• Serologically, DLE differs from SLE: antinuclear antibodies are frequently negative or present only at low titer, and the high-titer anti-dsDNA pattern characteristic of SLE is not a feature of skin-limited disease.
• Type I interferon activity is well established in cutaneous lupus and is the basis for interferon-directed therapeutic interest, so interferon-regulated soluble mediators and chemokines are informative circulating analytes.
• Serum is acellular and is the appropriate matrix for autoantibody testing, cytokine and chemokine immunoassays, and proteomic discovery. It does not support flow cytometry or other cell-based readouts.

Donor Stratification Available

• Localized versus generalized (disseminated) discoid disease
• Lesion distribution: head and neck only versus involvement below the neck; scalp involvement with scarring alopecia
• Antinuclear antibody status and titer where documented
• Absence versus presence of concurrent systemic lupus criteria, allowing skin-limited cohorts to be requested specifically
• Treatment status: topical or intralesional corticosteroid, antimalarial therapy, systemic immunosuppressant, or untreated
• Disease duration, Fitzpatrick skin type where available, plus age, sex, and self-reported race/ethnicity
• Matched healthy controls available

Product Features

• Collected from clinically confirmed DLE donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• Standard and custom aliquot volumes available
• IRB-approved protocols with documented electronic consent

De-identified Donor Data

• Diagnosis confirmation
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• Lesion distribution, serology, and treatment history where available
• Additional DLE-specific metadata on request

Applications

• Autoantibody detection and ANA assay development in skin-limited lupus
• Serum cytokine and chemokine profiling
• Interferon-regulated soluble analyte research
• Serum proteomics for cutaneous lupus biomarker discovery
• Comparative serology against systemic lupus and other cutaneous lupus subtypes
• Photosensitivity and UV response biomarker studies
• Therapeutic candidate screening and treatment-response research
• Disease-state matrix for immunoassay validation

Other Discoid Lupus Erythematosus Specimen Types

• Discoid Lupus Erythematosus Plasma
• Discoid Lupus Erythematosus Whole Blood
• Discoid Lupus Erythematosus PBMC
• Discoid Lupus Erythematosus Bulk Plasma
• Cutaneous Lupus Erythematosus Serum

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Discoid Lupus Erythematosus Serum is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse all matrices and disease states, visit our human serum page.