Discoid Lupus Erythematosus Serum
Discoid Lupus Erythematosus Serum - Human serum from IRB-consented donors with clinically confirmed DLE, the most common skin-limited form of chronic cutaneous lupus. Most DLE donors do not have systemic lupus. Ideal for cytokine and chemokine profiling, interferon-regulated analytes, ANA serology, and proteomic biomarker discovery.
Human Discoid Lupus Erythematosus Serum for Cutaneous Lupus Research
Our Discoid Lupus Erythematosus Serum is sourced from IRB-consented donors clinically diagnosed with discoid lupus erythematosus (DLE). Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for cytokine profiling, interferon-related analyte work, and serological studies. Research Use Only (RUO).
Cutaneous Lupus Biology and Why Serum
- Discoid lupus erythematosus is the most common form of chronic cutaneous lupus erythematosus. It is a skin-limited autoimmune disease, and most people with DLE do not have systemic lupus erythematosus. DLE should not be treated as an SLE surrogate.
- Lesions are well-demarcated, scaly, and often scarring, with follicular plugging and dyspigmentation; scalp involvement can produce scarring alopecia. Ultraviolet exposure is a recognized trigger.
- Histologically the disease is an interface dermatitis with a lymphocytic infiltrate at the dermoepidermal junction and around adnexal structures, indicating a cell-mediated, skin-directed autoimmune process.
- Serologically, DLE differs from SLE: antinuclear antibodies are frequently negative or present only at low titer, and the high-titer anti-dsDNA pattern characteristic of SLE is not a feature of skin-limited disease.
- Type I interferon activity is well established in cutaneous lupus and is the basis for interferon-directed therapeutic interest, so interferon-regulated soluble mediators and chemokines are informative circulating analytes.
- Serum is acellular and is the appropriate matrix for autoantibody testing, cytokine and chemokine immunoassays, and proteomic discovery. It does not support flow cytometry or other cell-based readouts.
Donor Stratification Available
- Localized versus generalized (disseminated) discoid disease
- Lesion distribution: head and neck only versus involvement below the neck; scalp involvement with scarring alopecia
- Antinuclear antibody status and titer where documented
- Absence versus presence of concurrent systemic lupus criteria, allowing skin-limited cohorts to be requested specifically
- Treatment status: topical or intralesional corticosteroid, antimalarial therapy, systemic immunosuppressant, or untreated
- Disease duration, Fitzpatrick skin type where available, plus age, sex, and self-reported race/ethnicity
- Matched healthy controls available
Product Features
- Collected from clinically confirmed DLE donors
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- Standard and custom aliquot volumes available
- IRB-approved protocols with documented electronic consent
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- Lesion distribution, serology, and treatment history where available
- Additional DLE-specific metadata on request
Applications
- Autoantibody detection and ANA assay development in skin-limited lupus
- Serum cytokine and chemokine profiling
- Interferon-regulated soluble analyte research
- Serum proteomics for cutaneous lupus biomarker discovery
- Comparative serology against systemic lupus and other cutaneous lupus subtypes
- Photosensitivity and UV response biomarker studies
- Therapeutic candidate screening and treatment-response research
- Disease-state matrix for immunoassay validation
Other Discoid Lupus Erythematosus Specimen Types
- Discoid Lupus Erythematosus Plasma
- Discoid Lupus Erythematosus Whole Blood
- Discoid Lupus Erythematosus PBMC
- Discoid Lupus Erythematosus Bulk Plasma
- Cutaneous Lupus Erythematosus Serum
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Discoid Lupus Erythematosus Serum is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse all matrices and disease states, visit our human serum page.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.