Heart Failure Serum
Heart Failure Serum samples are derived from donors diagnosed with heart failure. Useful for analyzing cardiac enzymes, oxidative stress markers, and metabolic profiles linked to heart failure pathophysiology.
Heart Failure Serum for Research
Our Heart Failure Serum products are sourced from IRB-consented donors clinically diagnosed with heart failure. Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for cardiovascular biomarker, metabolic, and immunological studies.
HFrEF vs HFpEF: Specify the Phenotype
Heart failure is a syndrome, not a single disease, and the two principal phenotypes differ enough that pooling them can obscure a real effect:
- HFrEF (reduced ejection fraction, LVEF ≤40%) — typically follows ischaemic injury or dilated cardiomyopathy, with neurohormonal activation as the dominant driver
- HFpEF (preserved ejection fraction, LVEF ≥50%) — associated with hypertension, obesity, diabetes, and systemic inflammation rather than contractile failure
- HFmrEF (mildly reduced, LVEF 41–49%) — an intermediate group increasingly studied separately
Because HFpEF is now understood as a substantially inflammatory and metabolic condition, serum from a defined phenotype is considerably more informative than an unstratified heart failure cohort.
Donor Stratification Available
- Ejection fraction and phenotype classification where recorded
- NYHA functional class I–IV
- Natriuretic peptides — BNP or NT-proBNP values where tested
- Aetiology — ischaemic vs non-ischaemic
- Comorbidities — diabetes, chronic kidney disease, atrial fibrillation, obesity
- Treatment status — including donors on ARNI, SGLT2 inhibitor, beta-blocker, or MRA therapy
Product Features
- Collected from clinically confirmed heart failure donors
- Research Use Only (RUO)
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
- Matched healthy control serum available
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and ethnicity
- Donor-reported medical history and comorbidities
- Cardiac functional data where available
Applications
- Biomarker discovery for heart failure, including natriuretic peptide and troponin work
- Fibrosis and remodeling marker studies (galectin-3, ST2)
- Serum cytokine and protein profiling
- Metabolomic profiling across HF phenotypes
- Diagnostic assay development and validation
- Therapeutic candidate screening and validation
Other Heart Failure Specimen Types
Matched material from heart failure donors is available as heart failure plasma, whole blood, and PBMC. Related cardiovascular cohorts include cardiomyopathy plasma.
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering and Customization
Heart failure serum is available in standard and custom volumes. For international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human serum collection.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.