Human Papillomavirus HPV Plasma
Human Papillomavirus HPV Plasma - Cryopreserved human plasma collected from clinically confirmed HPV donors. HPV plasma is ideal for examining inflammation and disease progression.
Human Papillomavirus (HPV) Plasma for Research
HPV Plasma is collected from donors clinically diagnosed with HPV and processed within hours of collection to preserve circulating nucleic acids alongside cytokines, proteins, and metabolites. This human plasma supports circulating HPV DNA detection, liquid biopsy development, and biomarker discovery in HPV-associated disease.
Plasma or Serum? Choose by Assay Type
For HPV, matrix choice is determined by what you are measuring:
- Plasma (this page) — the matrix for molecular work: circulating HPV DNA, cell-free DNA, circulating tumour DNA, and viral load quantification. Plasma is preferred over serum for cfDNA because the clotting process releases genomic DNA from leukocytes and dilutes the circulating fraction.
- Serum — the matrix for serology: anti-L1 VLP antibodies, neutralising titres, and vaccine-response work
Donor Stratification Available
- HPV type — high-risk types including 16 and 18, or low-risk types, where genotyped
- Clinical stage — infection, cytological abnormality, CIN grade, or invasive disease
- Anatomical site — cervical, oropharyngeal, anogenital
- Vaccination status where recorded
- Anticoagulant — EDTA standard for cfDNA work; Streck or other cell-stabilising tubes on request
- Matched HPV-negative controls available
Pre-Analytical Handling for Circulating DNA
Circulating tumour and viral DNA work is unusually sensitive to collection technique, so these are specified rather than assumed:
- Documented time from draw to separation, since delayed processing allows leukocyte lysis to swamp the cell-free fraction
- Double-spin protocol available to remove residual cellular material
- Cell-stabilising tube options for longer transit windows
- Aliquoted to minimise freeze-thaw
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed HPV donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
De-identified Donor Data
- Verified HPV diagnosis, with genotype where available
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Additional HPV-specific metadata available
Applications
- Circulating HPV DNA detection and quantification
- Liquid biopsy and ctDNA assay development
- HPV-associated oropharyngeal and cervical cancer monitoring research
- Genotyping assay validation
- Biomarker discovery and validation
- Cytokine and immune activation profiling
- Metabolomics and proteomics studies
- Therapeutic response research
Other HPV Specimen Types
Matched material from HPV-positive donors is available as HPV serum (for serology), whole blood, and HPV leukopak. For HPV-associated malignancy see cervical cancer serum.
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering and Customization
HPV plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.