Human Papillomavirus HPV Plasma

About Human Papillomavirus HPV Plasma

Human Papillomavirus (HPV) Plasma for Research

HPV Plasma is collected from donors clinically diagnosed with HPV and processed within hours of collection to preserve circulating nucleic acids alongside cytokines, proteins, and metabolites. This human plasma supports circulating HPV DNA detection, liquid biopsy development, and biomarker discovery in HPV-associated disease.

Plasma or Serum? Choose by Assay Type

For HPV, matrix choice is determined by what you are measuring:

• Plasma (this page) — the matrix for molecular work: circulating HPV DNA, cell-free DNA, circulating tumour DNA, and viral load quantification. Plasma is preferred over serum for cfDNA because the clotting process releases genomic DNA from leukocytes and dilutes the circulating fraction.
• Serum — the matrix for serology: anti-L1 VLP antibodies, neutralising titres, and vaccine-response work

Donor Stratification Available

• HPV type — high-risk types including 16 and 18, or low-risk types, where genotyped
• Clinical stage — infection, cytological abnormality, CIN grade, or invasive disease
• Anatomical site — cervical, oropharyngeal, anogenital
• Vaccination status where recorded
• Anticoagulant — EDTA standard for cfDNA work; Streck or other cell-stabilising tubes on request
• Matched HPV-negative controls available

Pre-Analytical Handling for Circulating DNA

Circulating tumour and viral DNA work is unusually sensitive to collection technique, so these are specified rather than assumed:

• Documented time from draw to separation, since delayed processing allows leukocyte lysis to swamp the cell-free fraction
• Double-spin protocol available to remove residual cellular material
• Cell-stabilising tube options for longer transit windows
• Aliquoted to minimise freeze-thaw

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed HPV donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified HPV diagnosis, with genotype where available
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Additional HPV-specific metadata available

Applications

• Circulating HPV DNA detection and quantification
• Liquid biopsy and ctDNA assay development
• HPV-associated oropharyngeal and cervical cancer monitoring research
• Genotyping assay validation
• Biomarker discovery and validation
• Cytokine and immune activation profiling
• Metabolomics and proteomics studies
• Therapeutic response research

Other HPV Specimen Types

Matched material from HPV-positive donors is available as HPV serum (for serology), whole blood, and HPV leukopak. For HPV-associated malignancy see cervical cancer serum.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering and Customization

HPV plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.