Lupus Nephritis Plasma
Lupus Nephritis Plasma - Cryopreserved human plasma from IRB-consented donors with clinically confirmed lupus nephritis, the renal manifestation of SLE. Ideal for anti-dsDNA and complement work, cytokine profiling, proteomics, and renal activity biomarker discovery. Stratification by ISN/RPS histological class, activity, and treatment. Acellular matrix.
Lupus Nephritis Plasma for Autoimmune Kidney Disease Research
Lupus Nephritis Plasma is collected from IRB-consented donors clinically diagnosed with lupus nephritis and processed within one day of collection to preserve labile analytes such as complement components, cytokines, proteins, and metabolites. Cryopreserved and available in custom aliquot volumes. Research Use Only (RUO).
Disease Mechanism and Why Plasma
- Lupus nephritis is the renal manifestation of systemic lupus erythematosus, an autoimmune disease driven by loss of tolerance to nuclear antigens and by antinuclear and anti-double-stranded DNA autoantibodies.
- Renal injury is initiated by deposition of nucleic acid-containing immune complexes in the glomerulus, followed by complement activation, leukocyte recruitment, and glomerular inflammation. Consumption of complement, with low C3 and C4, accompanies active renal disease.
- Histological class under the ISN/RPS system, from mesangial through proliferative to membranous patterns, determines treatment and prognosis and is the single most important stratifier for interpreting biomarker data.
- Anti-dsDNA titers and complement levels are established, measurable circulating correlates of renal activity, and anti-C1q antibodies have been studied in the same context.
- Many candidate lupus nephritis activity markers are urinary rather than circulating. Plasma is the correct matrix for autoantibody, complement, systemic cytokine, and renal function analyte measurement, and is often paired with urine in study designs.
- Plasma is acellular. This product supports soluble analyte, proteomic, and metabolomic work, not flow cytometry or other cell-based assays.
Donor Stratification Available
- Biopsy-proven ISN/RPS histological class where documented
- Renal disease activity: active nephritis versus remission or low activity
- Degree of proteinuria and estimated glomerular filtration rate category
- Autoantibody and complement status: anti-dsDNA titer, low C3 or C4
- Treatment status: mycophenolate, cyclophosphamide, calcineurin inhibitor, biologic therapy, corticosteroid, or treatment-naive
- Extrarenal SLE manifestations, disease duration, age, sex, and self-reported race/ethnicity
- Matched healthy controls available; SLE donors without renal involvement available as disease controls
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed lupus nephritis donors
- Processed within one day of collection
- Cryopreserved for long-term stability
- IRB-approved protocols and electronic informed consent
- Custom aliquot volumes and anticoagulant options available upon request; paired urine available on request
De-identified Donor Data
- Verified lupus nephritis diagnosis
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Renal histology class, proteinuria, and renal function values where available
- Additional lupus nephritis-specific metadata available on request
Applications
- Anti-dsDNA and anti-nuclear autoantibody assay development
- Complement activation and immune complex research
- Cytokine, chemokine, and inflammatory mediator profiling
- Plasma proteomics for renal activity and flare-prediction biomarker discovery
- Renal function analyte measurement and kidney injury marker research
- Metabolomic analysis in autoimmune renal disease
- Treatment response and remission-induction biomarker studies
- Disease-state matrix for immunoassay development and validation
Other Lupus Nephritis Specimen Types
- Lupus Nephritis Serum
- Lupus Nephritis Whole Blood
- Lupus Nephritis PBMC
- Lupus Nephritis Leukopak
- Systemic Lupus Erythematosus Plasma
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Lupus Nephritis Plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse all matrices and disease states, visit our human plasma page.
Protocols & Documentation
-
Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
-
Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Frequently Asked Questions
1 Answer
YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
1 Answer
YES – all our products are research use only (RUO).
1 Answer
You can find our full product catalog here.
1 Answer
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
1 Answer
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
1 Answer
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
1 Answer
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
1 Answer
YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
1 Answer
Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
1 Answer
YES – Unique donors can be specified and guaranteed based on your requirements.
1 Answer
For information about sample quality, please see: Quality and Compliance
1 Answer
YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.