Systemic Lupus Erythematosus Plasma

Systemic Lupus Erythematosus Plasma for Autoimmune and Interferon Pathway Research

Systemic Lupus Erythematosus (SLE) Plasma is collected from IRB-consented donors clinically diagnosed with SLE and processed within hours of collection to preserve cytokines, complement components, circulating nucleic acids, and metabolites. This human plasma supports research into immune complex biology, interferon signalling, and biomarker discovery in SLE. Bulk plasma is available.

Why Plasma for Systemic Lupus Erythematosus Research

SLE is a systemic autoimmune disease in which tolerance to nucleic acid–containing self antigens is lost. Its pathology is largely mediated by circulating immune complexes and the interferon response they trigger, which makes the fluid phase of blood the site of action. Plasma is collected with anticoagulant and separated without a clotting step, which is important for complement fragments and cell-free nucleic acids that clotting perturbs.

• Immune complexes are the pathogenic unit — antibodies against double-stranded DNA, Smith antigen, and other ribonucleoproteins form complexes that deposit in tissue and activate complement; plasma is where they circulate
• Complement consumption is a direct disease readout — falling C3 and C4 with rising activation fragments reflects active complement turnover, and anticoagulated plasma is the preferred matrix for complement fragment work
• Type I interferon signature — nucleic acid–containing complexes engage TLR7 and TLR9 in plasmacytoid dendritic cells, driving the interferon response that anti-interferon receptor therapy targets; interferon-inducible proteins are measurable in plasma
• Cell-free DNA and nucleosomes — impaired clearance of apoptotic material leaves circulating nucleosomes and cell-free DNA that are both antigen source and candidate biomarker, and require unclotted plasma to measure reliably
• B cell survival signalling — BAFF is elevated in SLE and is the target of established B cell–directed therapy, making it a natural plasma analyte for stratification
• Activity is dynamic — SLE alternates between flare and quiescence, so serial or activity-defined sampling is far more informative than a single unclassified draw

Donor Stratification Available

• Disease activity — SLEDAI or physician-rated activity where recorded; flare versus quiescent disease at draw
• Autoantibody profile — anti-dsDNA, anti-Sm, anti-RNP, anti-Ro, and antiphospholipid antibody status where measured
• Complement status — C3 and C4 levels reported per lot where available
• Renal involvement — biopsy-proven or clinically diagnosed lupus nephritis versus non-renal SLE
• Organ involvement — cutaneous, articular, haematological, or neuropsychiatric manifestations where documented
• Treatment status — hydroxychloroquine, corticosteroids, mycophenolate or other immunosuppressant, or biologic therapy including B cell– and interferon-directed agents
• Matched healthy controls available — demographically matched healthy donor plasma

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed Systemic Lupus Erythematosus (SLE) donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes and anticoagulant types available upon request

De-identified Donor Data

• Confirmed SLE diagnosis by physician or specialist
• Demographic details: age, sex assigned at birth, ethnicity
• Medical history including allergies and infectious disease status
• Disease activity, autoantibody status, and laboratory values available on request
• Explore our SLE Donor Network

Applications

• Circulating immune complex and complement activation research
• Type I interferon signature and interferon-inducible protein measurement
• Cell-free DNA, nucleosome, and extracellular vesicle analysis
• BAFF and B cell activation marker profiling
• Cytokine and chemokine profiling across flare and remission
• Lupus nephritis biomarker discovery and renal risk stratification
• Proteomic and metabolomic profiling
• Therapeutic response research for B cell– and interferon-directed agents

Other Systemic Lupus Erythematosus Specimen Types

Matched material from the same SLE donor pool is available as SLE serum, whole blood, PBMC, leukopak, and synovial fluid. Tissue is available as lupus skin punch biopsy, and isolated subsets as CD19+ B cells and CD4+ T cells.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Systemic Lupus Erythematosus plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse the full specimen range and healthy-donor controls, see our human plasma collection.