Myasthenia Gravis Whole Blood
Powered by BiozAbout:Fresh whole blood from consented donors with confirmed myasthenia gravis, an autoimmune disorder of the neuromuscular junction. Useful for AChR and MuSK autoantibody research, complement inhibitor and FcRn antagonist studies, and B cell immunophenotyping. Autoantibody and subtype stratification available.
About Myasthenia Gravis Whole Blood
Myasthenia Gravis Whole Blood for Neuroimmunology Research
Myasthenia Gravis Whole Blood is collected from IRB-consented donors with a clinically confirmed myasthenia gravis diagnosis, then shipped same day to preserve cellular and plasma analytes. Myasthenia gravis is an autoimmune disorder of the neuromuscular junction in which autoantibodies interfere with postsynaptic signalling, producing fluctuating, fatigable muscle weakness. These fresh samples support neuroimmunology, autoantibody and therapeutic response research.
Neuromuscular Junction Autoimmunity and Why Whole Blood
- Most patients have IgG autoantibodies against the postsynaptic nicotinic acetylcholine receptor (AChR). These antibodies impair neuromuscular transmission through receptor blockade, cross-linking and internalisation, and complement-mediated damage to the postsynaptic membrane.
- A distinct minority of patients instead carry antibodies to muscle-specific kinase (MuSK) or to LRP4; these subgroups differ clinically and in treatment response, so autoantibody status is a primary stratification variable.
- Complement activation at the endplate is a validated therapeutic target, and complement inhibitors are now part of the treatment landscape — making intact complement-containing samples valuable for mechanistic work.
- Thymic pathology, including thymic hyperplasia and thymoma, is associated with AChR-antibody positive disease and links the condition to abnormal central tolerance.
- Whole blood retains both the cellular compartment and the antibody- and complement-containing plasma fraction in native proportions, allowing paired serological and cellular analysis from a single draw.
- Because whole blood is cellular, it supports immunophenotyping, B cell and plasmablast characterisation, and RNA-based profiling in addition to autoantibody quantification.
Donor Stratification Available
- Autoantibody status: AChR-positive, MuSK-positive, or seronegative
- Disease distribution: ocular versus generalized myasthenia gravis
- Thymic status where documented, including thymoma-associated disease and prior thymectomy
- Treatment status: acetylcholinesterase inhibitors, corticosteroids, non-steroidal immunosuppressants, complement inhibitors, FcRn antagonists, or treatment-naive
- Early versus late onset disease and time since diagnosis
- Matched healthy controls available
Product Features
- Fresh whole blood from clinically diagnosed myasthenia gravis donors
- Custom anticoagulants and collection tubes available
- Same-day collection and shipment
- Custom volumes available on request
- Research Use Only (RUO)
De-identified Donor Data
- Physician-confirmed diagnosis, including autoantibody status where available
- Demographics: age, sex assigned at birth, ethnicity
- Relevant medical and treatment history
- Disease distribution and severity where documented
Applications
- AChR, MuSK and LRP4 autoantibody assay development and validation
- Complement activation and complement inhibitor mechanism research
- FcRn antagonist and IgG recycling pharmacodynamic studies
- B cell, plasmablast and T follicular helper cell immunophenotyping
- Neuromuscular junction biomarker discovery
- Gene expression and transcriptomic analysis
- Biologic and immunosuppressant therapy response research
- Whole blood stimulation and cytokine release assay development
Other Myasthenia Gravis Specimen Types
- Myasthenia Gravis Plasma
- Myasthenia Gravis Serum
- Myasthenia Gravis PBMC
- Myasthenia Gravis Leukopak
- Myasthenia Gravis Bulk Plasma
Looking for a specific MG subtype in whole blood? See our AChR+, Generalized, Ocular, and Seronegative Myasthenia Gravis Whole Blood products.
Compliance and Quality Assurance
- IRB-approved protocols and electronic informed consent
- HIPAA-compliant donor data handling
Ordering & Customization
Myasthenia gravis whole blood is available in standard and custom volumes. For pricing, current availability, international orders or documentation requirements, email learnmore@sanguinebio.com. To browse donor cohorts across our full inventory, visit our human whole blood page.
Applications
- Hematology and clinical chemistry research
- Plasma, serum, and PBMC isolation
- Flow cytometry and biomarker studies
- Drug-spike and ex vivo stimulation assays
Product Features
- Research Use Only (RUO), human whole blood
- Collected from screened, consented donors
- Available in EDTA, sodium heparin, ACD, or citrate anticoagulants
- Shipped fresh under temperature-controlled conditions
- Drawn and shipped same day of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Whole Blood are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Whole Blood
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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View InventoryNeed a custom Whole Blood cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.