Myasthenia Gravis Plasma
About:Myasthenia Gravis Plasma - Cryopreserved human plasma from clinically confirmed myasthenia gravis donors. Ideal for profiling AChR and MuSK autoantibodies, complement proteins, and inflammatory cytokines, with AChR-positive, MuSK-positive, and seronegative donors available.
About Myasthenia Gravis Plasma
Myasthenia Gravis Plasma for Autoimmune Neuromuscular Junction Research
Myasthenia Gravis Plasma is collected from IRB-consented donors clinically diagnosed with myasthenia gravis (MG) and processed within one day of collection to preserve autoantibodies, complement proteins, cytokines, and other labile analytes. MG is an antibody-mediated autoimmune disease of the neuromuscular junction: pathogenic IgG autoantibodies against the postsynaptic acetylcholine receptor (AChR) or muscle-specific kinase (MuSK) impair neuromuscular transmission, producing fatigable weakness.
Disease Biology and Why Plasma
- AChR autoantibodies are present in the majority of generalised MG donors and act through complement-mediated damage to the postsynaptic membrane, receptor cross-linking and internalisation, and direct blockade of acetylcholine binding.
- MuSK autoantibodies define a distinct, predominantly IgG4 subgroup that disrupts agrin-LRP4-MuSK signalling and postsynaptic AChR clustering rather than acting through complement.
- Complement activation is central to AChR-positive disease and is the target of approved therapeutics; plasma preserves complement components and activation products for pathway analysis.
- Seronegative and low-affinity antibody donors support cell-based assay development and discovery of additional autoantigens such as LRP4 and agrin.
- IgG-directed therapeutics: FcRn antagonists and complement inhibitors are assessed through circulating total IgG and antibody titre, both plasma-appropriate readouts.
- Plasma is acellular and is the correct matrix for autoantibody titration, complement profiling, cytokine multiplexing, proteomics, and metabolomics. For cellular assays, see the PBMC and leukopak products below.
Donor Stratification Available
- Serostatus: AChR-positive, MuSK-positive, or seronegative
- Clinical subtype: ocular versus generalised MG
- Thymic pathology: thymoma-associated, thymic hyperplasia, or post-thymectomy
- Age at onset: early-onset versus late-onset disease
- Treatment status: acetylcholinesterase inhibitors, corticosteroids, non-steroidal immunosuppressants, rituximab, complement inhibitors, FcRn antagonists, IVIg or plasma exchange, or treatment-naive
- Disease activity: stable, exacerbation, or history of myasthenic crisis
- Matched healthy controls available
Product Features
- Research Use Only (RUO)
- Plasma collected from clinically confirmed MG donors
- Processed within one day of collection
- IRB-approved protocols and informed consent
- Custom aliquot volumes available upon request
De-identified Donor Data
- Verified MG diagnosis
- Serostatus (AChR, MuSK) where available
- Demographic data: age, sex assigned at birth, race/ethnicity
- Donor-reported medications, allergies, and comorbidities
- Additional myasthenia gravis-specific metadata available
Applications
- AChR and MuSK autoantibody detection, titration, and isotype analysis
- Radioimmunoassay, ELISA, and cell-based assay development and validation
- Complement activation and complement inhibitor pharmacodynamic research
- FcRn antagonist and IgG-lowering therapeutic research
- Novel autoantigen discovery in seronegative donors
- Cytokine and inflammation profiling
- Proteomic and metabolomic biomarker discovery
- Treatment response and disease activity biomarker studies
Other Myasthenia Gravis Specimen Types
MG donor material is also available as Myasthenia Gravis Serum, Myasthenia Gravis PBMC, Myasthenia Gravis Whole Blood, Myasthenia Gravis Leukopak, and Myasthenia Gravis Bulk Plasma for larger-volume requirements. Subtype-specific plasma is available as AChR+ Myasthenia Gravis Plasma, Ocular Myasthenia Gravis Plasma, Generalized Myasthenia Gravis Plasma, and Seronegative Myasthenia Gravis Plasma.
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Myasthenia gravis plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Plasma
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Plasma are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Plasma Isolation
Protocol for plasma separation from anticoagulated whole blood, including processing, storage, and traceability requirements.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Plasma
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Healthy Plasma
207 In Stock View InventoryNeed a custom Plasma cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.