Parkinson’s Disease PBMC
Powered by BiozAbout:Parkinson's Disease PBMC samples are collected from IRB-consented donors with clinically confirmed Parkinson's disease and cryopreserved in CryoStor CS10. Ideal for peripheral immune profiling, transcriptomics, mitochondrial and lysosomal pathway assays, LRRK2 and GBA1 genotyping, and iPSC reprogramming. Age- and sex-matched healthy controls available.
About Parkinson’s Disease PBMC
Parkinson’s Disease PBMC for Neurodegeneration and Peripheral Immunology Research
Parkinson’s Disease Human PBMC products are sourced from IRB-consented donors clinically diagnosed with Parkinson’s disease, processed within 24 hours of collection and cryopreserved in CryoStor CS10. These peripheral blood mononuclear cells support genetic, transcriptomic and cellular immunology work in a neurodegenerative disease.
Parkinson’s Disease Biology and Why PBMC
Parkinson’s disease is a neurodegenerative disorder, not an autoimmune disease. Its defining pathology is progressive loss of dopaminergic neurons in the substantia nigra together with intracellular alpha-synuclein aggregation.
- Alpha-synuclein misfolding and aggregation into Lewy pathology is the central molecular event, and peripheral cells are used to study handling of alpha-synuclein and related proteostasis machinery
- Loss of nigrostriatal dopaminergic neurons produces the motor phenotype and underlies dopaminergic pharmacotherapy
- Common genetic risk variants in LRRK2 and GBA1 are among the best established in the field, and PBMC provide accessible genomic DNA and matched living cells from carriers
- Mitochondrial and lysosomal-autophagy pathway dysfunction, including PINK1 and PRKN biology, is measurable in peripheral mononuclear cells
- Peripheral immune involvement is an active research area rather than a settled mechanism: altered monocyte and T cell phenotypes have been reported in Parkinson’s cohorts, and this is the main scientific justification for a PBMC product
- PBMC also support iPSC reprogramming for patient-derived neuronal models, plus flow cytometry, single-cell RNA sequencing and ex vivo functional assays
Donor Stratification Available
- Disease stage by clinician assessment, where recorded
- Disease duration since diagnosis
- Genetic status where available, including LRRK2 and GBA1 variant carriers
- Treatment status: levodopa-treated, dopamine agonist-treated, or treatment-naive
- Motor phenotype, including tremor-dominant versus postural instability and gait difficulty
- Presence or absence of documented cognitive involvement
- Matched healthy controls available, age- and sex-matched on request
Product Features
- Research Use Only (RUO), cryopreserved PBMCs
- Clinically confirmed Parkinson’s disease donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Stored using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screen LeukoLot™ available prior to bulk orders
De-identified Donor Data
- Verified Parkinson’s disease diagnosis
- Donor demographics: age, sex assigned at birth, race/ethnicity
- Self-reported allergies and infectious disease history
- Medication history, including dopaminergic therapy
- Additional Parkinson’s disease-specific data available upon request
Applications
- Peripheral immune cell phenotyping in neurodegeneration
- Single-cell and bulk transcriptomic profiling
- Genomic DNA extraction for LRRK2, GBA1 and polygenic risk genotyping
- Mitochondrial function and mitophagy assays in primary human cells
- Lysosomal and autophagy pathway research, including glucocerebrosidase activity
- iPSC reprogramming and patient-derived neuronal model generation
- Target validation and compound screening for disease-modifying candidates
- Biomarker discovery against age- and sex-matched healthy controls
Other Parkinson’s Disease Specimen Types
- Parkinson’s Disease Plasma
- Parkinson’s Disease Serum
- Parkinson’s Disease Whole Blood
- Parkinson’s Disease Cerebrospinal Fluid
Compliance and Quality Assurance
- IRB-approved collections and protocols
- 21 CFR Part 11 – compliant e-consent system
- HIPAA-compliant donor data protection
Ordering & Customization
Parkinson’s Disease PBMC samples are shipped on dry ice and available in custom aliquots. For pricing, availability, international orders or regulatory requirements, please contact learnmore@sanguinebio.com to confirm documentation and compliance needs. To browse PBMC from other disease states and check live stock status, visit our human PBMC page.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human PBMC are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
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Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
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Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Healthy PBMC
806 In Stock View InventoryNeed a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.