Peanut Allergy Plasma

About Peanut Allergy Plasma

Peanut Allergy Plasma for IgE-Mediated Food Allergy Research

Peanut Allergy Plasma is collected from IRB-consented donors clinically diagnosed with peanut allergy and processed within one day of collection to preserve cytokines, proteins, and metabolites. Peanut allergy is a type I, IgE-mediated hypersensitivity: allergen-specific IgE bound to FcepsilonRI on mast cells and basophils is cross-linked by peanut proteins, triggering immediate degranulation. It is an allergic disease of the type 2 immune axis, not an autoimmune one, and plasma supports research into the soluble mediators and systemic changes involved.

Why Plasma for Peanut Allergy Research

• The effector step in peanut allergy is mast cell and basophil degranulation. Plasma is a practical matrix for measuring histamine metabolites, tryptase and other released mediators, and for interrogating the systemic footprint of an allergic reaction.
• The type 2 cytokines that sustain IgE production — IL-4, IL-13 and IL-5 — and the epithelial alarmins upstream of them are measurable in plasma by multiplex immunoassay.
• Plasma is separated without a clotting step, which avoids the ex vivo platelet degranulation that inflates platelet-stored chemokines in serum. This matters for chemokine panels in allergy research.
• Oral immunotherapy for peanut allergy reshapes the humoral response, with rising allergen-specific IgG4 and a shifting IgE-to-IgG4 balance being among the best-characterised immunological correlates of desensitisation. Plasma from treated and untreated donors supports this comparison.
• Anti-IgE therapy is now an established approach in food allergy, making free and total IgE and receptor occupancy research directly relevant to plasma-based pharmacodynamic work.
• A technical note on matrix choice: quantitative allergen-specific IgE and component-resolved diagnostics are conventionally performed in serum, where the published reference data sit. Use the serum product for component-resolved IgE work and plasma for mediator, cytokine and omics studies.

Donor Stratification Available

• Peanut-specific IgE level and total IgE where available
• Component sensitisation profile, including Ara h 2 status where tested
• Diagnosis basis: oral food challenge-confirmed, or clinical history with supportive specific IgE or skin prick testing
• Reaction severity and documented history of anaphylaxis or epinephrine use
• Treatment status: oral immunotherapy-naive, currently on oral immunotherapy, maintenance phase, or on anti-IgE therapy
• Co-existing food allergies and atopic comorbidity, including asthma and atopic dermatitis
• Age group, including paediatric and adult donors
• Matched non-allergic healthy controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed peanut allergy donors
• Processed within one day of collection
• Anticoagulant selection available on request
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified peanut allergy diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Reaction history and immunotherapy status where available
• Additional peanut allergy-specific metadata available on request

Applications

• Mast cell and basophil mediator profiling, including tryptase
• Type 2 cytokine and chemokine multiplex panels
• Biomarker discovery for reaction threshold, severity and natural tolerance acquisition
• Immunological monitoring of oral immunotherapy and desensitisation research
• Free and total IgE measurement for anti-IgE pharmacodynamic studies
• Proteomic and metabolomic profiling of the food-allergic state
• Assay development and validation using disease-state plasma as a clinically relevant matrix
• Comparative study of peanut allergy against other IgE-mediated food allergies

Other Peanut Allergy Specimen Types

• Peanut Allergy Serum
• Peanut Allergy Whole Blood
• Peanut Allergy PBMC
• Peanut Allergy Leukopak
• Peanut Allergy Bulk Plasma

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Peanut allergy plasma is available in standard and custom volumes. For pricing, availability, or to discuss a cohort stratified by specific IgE level or immunotherapy status, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse plasma across all disease states and healthy donors, visit our human plasma page.