Peanut Allergy Serum
Powered by BiozAbout:Peanut Allergy Serum — human serum from consented donors with clinically confirmed peanut allergy, processed and frozen within 24 hours of collection. Serum is the reference matrix for total and allergen-specific IgE and for component-resolved diagnostics using Ara h 2 and related peanut components. Donors can be stratified by specific IgE level, challenge-confirmed diagnosis, reaction severity, and oral immunotherapy status.
About Peanut Allergy Serum
Human Peanut Allergy Serum for IgE and Allergen Component Research
Our Peanut Allergy Serum is sourced from IRB-consented donors clinically diagnosed with peanut allergy. Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for allergy immunology and diagnostic development. Peanut allergy is a type I, IgE-mediated hypersensitivity in which allergen-specific IgE bound to FcepsilonRI on mast cells and basophils is cross-linked by peanut protein, producing immediate degranulation — an allergic mechanism, not an autoimmune one.
Why Serum for Peanut Allergy Research
- Serum is the reference matrix for quantitative allergen-specific IgE. The clinical assays and the published thresholds relating specific IgE concentration to reaction probability were established in serum, making it the correct choice for comparability.
- Component-resolved diagnostics rests on serum: sensitisation to the individual peanut storage proteins Ara h 1, Ara h 2, Ara h 3 and Ara h 6 carries different clinical weight, with Ara h 2 the most clinically informative single component.
- Allergen-specific IgG4 rises during oral immunotherapy, and the balance between specific IgE and specific IgG4 is one of the best-characterised serological correlates of desensitisation. Both isotypes are measured in serum.
- Serum from allergic donors serves as the IgE source for indirect basophil activation and passive sensitisation assays, where donor serum is used to sensitise reporter cells from a non-allergic donor.
- Cross-reactivity between peanut and tree nut or legume allergens is a serological question, addressed by inhibition and component profiling in serum rather than by cellular assay.
- Because serum contains no anticoagulant, it avoids citrate or EDTA interference on the immunoassay and mass spectrometry platforms most commonly used in allergy diagnostics.
Donor Stratification Available
- Peanut-specific IgE level and total IgE where available
- Component sensitisation profile, including Ara h 2 status where tested
- Diagnosis basis: oral food challenge-confirmed, or clinical history with supportive specific IgE or skin prick testing
- Reaction severity and documented history of anaphylaxis or epinephrine use
- Treatment status: oral immunotherapy-naive, currently on oral immunotherapy, maintenance phase, or on anti-IgE therapy
- Co-existing tree nut or other food allergies and atopic comorbidity
- Age group, including paediatric and adult donors
- Matched non-allergic healthy controls available
Product Features
- Collected from clinically confirmed peanut allergy donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
- High-titre donor selection available on request; specific IgE values reported per lot where tested
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and race/ethnicity
- Donor-reported allergy and infectious disease history
- Reaction history and immunotherapy status where available
- Additional peanut allergy-specific metadata available on request
Applications
- Total and allergen-specific IgE assay development and validation
- Component-resolved diagnostic development using individual Ara h allergens
- Specific IgG4 measurement and IgE-to-IgG4 ratio research in oral immunotherapy
- Indirect basophil activation and passive sensitisation assays
- Allergen cross-reactivity and inhibition studies
- Epitope mapping and allergen microarray work
- Biomarker discovery for reaction threshold, severity and tolerance acquisition
- Reference and control material for allergy diagnostic platforms
Other Peanut Allergy Specimen Types
- Peanut Allergy Plasma
- Peanut Allergy Whole Blood
- Peanut Allergy PBMC
- Peanut Allergy Leukopak
- Peanut Allergy Bulk Plasma
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Peanut allergy serum is available in standard and custom volumes. For pricing, availability, or to discuss a cohort stratified by specific IgE level or component profile, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse serum across all disease states and healthy donors, visit our human serum page.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Serum
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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102 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.