Type 2 Diabetes CD56+ NK Cells
About:Type 2 Diabetes CD56+ NK Cells are sourced from donors with T2D. These samples enable investigation into NK cell alterations in chronic low-grade inflammation, insulin resistance, and metabolic-immune cross-talk.
About Type 2 Diabetes CD56+ NK Cells
Type 2 Diabetes CD56+ NK Cells for Immunometabolism Research
Type 2 Diabetes CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with Type 2 Diabetes. These CD56+ CD3− natural killer cells reflect the innate immune alterations accompanying insulin resistance and support studies of immune surveillance, cytotoxicity, and metabolic-immune cross-talk.
NK Cells in Type 2 Diabetes
Type 2 diabetes is a metabolic disease of insulin resistance rather than an autoimmune one, but the innate compartment is measurably altered — and NK cells sit at an interesting junction between metabolism and immune surveillance:
- Impaired cytotoxicity and degranulation, reported consistently in hyperglycaemic donors
- Reduced activating receptor expression — NKG2D and natural cytotoxicity receptors are downregulated, which is one proposed mechanism behind the increased infection and malignancy risk in poorly controlled diabetes
- Adipose tissue NK populations that contribute to local inflammation and macrophage recruitment in expanding fat
- Glucose-dependent functional changes — NK effector function is metabolically demanding and sensitive to the hyperglycaemic environment
- Altered CD56-bright and CD56-dim balance, shifting the cytokine-producing versus cytotoxic split
Donor Stratification Available
- Glycaemic control — HbA1c and fasting glucose where tested, which is the variable most likely to explain NK functional differences
- BMI and obesity status
- Disease duration — newly diagnosed vs long-standing
- Treatment status — diet-controlled, metformin, GLP-1 receptor agonist, SGLT2 inhibitor, or insulin
- Complications — nephropathy, retinopathy, neuropathy where documented
- Matched controls — non-diabetic, and BMI-matched where obesity must be separated from diabetes
Product Features
- Research Use Only (RUO), CD56+ enriched NK cells
- Isolated from clinically diagnosed Type 2 Diabetes donors
- High viability and enrichment
- Cryopreserved in CryoStor® CS10 media
- Processed within 24 hours of collection
- Flow cytometry purity and viability data per lot
- Ethically sourced with IRB approval and HIPAA compliance
De-identified Donor Data
- Confirmed diagnosis of Type 2 Diabetes
- Demographics: age, sex assigned at birth, race/ethnicity
- Self-reported clinical history and medication use
Applications
- NK cell phenotype and function studies in Type 2 Diabetes
- Immunometabolism and meta-inflammation research
- Cytotoxicity, degranulation, and activating receptor assays
- Infection and malignancy susceptibility mechanism research
- CD56-bright vs CD56-dim subset analysis
- Single-cell analysis and disease mechanism studies
- Biomarker identification and preclinical immunotherapy development
Other Type 2 Diabetes Specimen Types
Matched material is available as T2D CD3+ T cells, CD19+ B cells, PBMC, serum, plasma, whole blood, leukopak, and bulk apheresis plasma.
Compliance and Quality Assurance
- IRB-approved collection and 21 CFR Part 11–compliant e-consent
- Standardized processing and quality protocols
- HIPAA-compliant data handling
Ordering & Customization
Type 2 Diabetes CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), CD56+ NK Cells
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human CD56+ NK Cells are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Need a custom CD56+ NK Cells cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.