Type 2 Diabetes CD19+ B Cells
Powered by BiozAbout:Type 2 Diabetes CD19 B Cells are isolated from peripheral blood of IRB-consented donors. Useful for studies of metabolic inflammation, insulin resistance, and immune-metabolic cross-talk.
About Type 2 Diabetes CD19+ B Cells
Type 2 Diabetes CD19+ B Cells for Immunometabolism Research
Type 2 Diabetes CD19+ B Cells are purified from peripheral blood of IRB-consented adult donors diagnosed with Type 2 Diabetes (T2D). These B lymphocytes support studies of metabolic inflammation, immune-metabolic cross-talk, and the B cell contribution to insulin resistance. Cryopreserved for optimal viability.
B Cells in Type 2 Diabetes
Type 2 diabetes is a metabolic disease driven by insulin resistance and progressive beta-cell dysfunction — distinct from the autoimmune beta-cell destruction of type 1 diabetes. Its immunology is nonetheless substantial, and B cells are active participants in what is now generally termed meta-inflammation: the chronic, low-grade inflammatory state accompanying obesity and insulin resistance.
- Pro-inflammatory cytokine skewing — increased IL-6 and TNF-α production from B cells in insulin-resistant donors
- Reduced regulatory B cell function — diminished IL-10-producing Breg populations, weakening a normally restraining signal
- Adipose tissue B cell infiltration, implicated in sustaining local inflammation
- Altered B cell subset distribution, with shifts in memory and naive compartments
- T cell–supporting function — B cells act as antigen-presenting cells that help sustain the inflammatory milieu
Because these effects track with metabolic parameters rather than autoimmunity, donor metabolic annotation matters more here than serological status.
Donor Stratification Available
- Glycaemic control — HbA1c and fasting glucose where tested
- BMI and obesity status, given the tight link to meta-inflammation
- Disease duration — newly diagnosed vs long-standing
- Treatment status — diet-controlled, metformin, GLP-1 receptor agonist, SGLT2 inhibitor, or insulin
- Complications — diabetic nephropathy, retinopathy, neuropathy where documented
- Matched non-diabetic controls, BMI-matched where the question requires separating obesity from diabetes
Product Features
- Research Use Only (RUO), CD19+ B cells
- Isolated from T2D donors with confirmed clinical diagnosis
- High purity and viability
- Cryopreserved using CryoStor® CS10 media
- Processed within 24 hours of collection
- Flow cytometry purity and viability data per lot
- IRB-approved protocols and HIPAA-compliant handling
De-identified Donor Data
- Confirmed diagnosis of T2D
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and clinical history available
Applications
- Immunometabolism and meta-inflammation research
- Disease-specific B cell profiling and immune phenotyping
- Regulatory B cell (Breg) and IL-10 function studies
- BCR signalling and B cell activation studies
- Insulin resistance and immune cross-talk modelling
- Biomarker discovery and therapeutic target validation
Other Type 2 Diabetes Specimen Types
Matched material from T2D donors is available as T2D serum, whole blood, and leukopak. For diabetic complications see diabetic nephropathy and chronic kidney disease cohorts.
Compliance and Quality Assurance
- IRB-approved collections with 21 CFR Part 11–compliant e-consent
- Standardized processing and cryopreservation protocols
- HIPAA-compliant donor data protection
Ordering & Customization
Type 2 Diabetes CD19+ B Cells are available in standard or custom aliquot sizes. For pricing, international shipping, documentation, or regulatory support, please contact learnmore@sanguinebio.com. For the full range, see our human CD19+ B cells collection.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), CD19+ B Cells
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human CD19+ B Cells are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
CD19+ B Cells
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Need a custom CD19+ B Cells cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.