Allergy Plasma

About Allergy Plasma

Allergy Plasma for Type 2 Immunity and Allergic Disease Research

Allergy Plasma is collected from IRB-consented donors with clinically diagnosed allergic disease and processed within one day of collection to preserve labile analytes such as immunoglobulins, cytokines, proteins and metabolites. Because plasma is acellular, it is supplied for soluble-analyte work — specific IgE and IgG4 serology, mediator quantification, proteomics and metabolomics — in standard or custom aliquot volumes with de-identified clinical annotation.

Why Allergy Plasma for Type 2 Immunity Research

Allergic disease is driven by type 2 immunity, not autoimmunity. On first exposure, allergen-specific Th2 cells and type 2 innate lymphoid cells release IL-4, IL-5 and IL-13, driving B cells to class-switch to IgE. That IgE binds FcεRI on mast cells and basophils, and re-exposure crosslinks it to trigger degranulation. Almost every element of that axis that can be measured is a circulating soluble protein.

• Total and allergen-specific IgE — the defining serological readout of sensitisation, and the analyte behind component-resolved diagnostic panels.
• Type 2 cytokines — IL-4, IL-5, IL-13 and TSLP-driven mediators circulate at low abundance and are the direct targets of current biologic therapies.
• Eosinophil and mast cell products — eosinophil cationic protein, eosinophil-derived neurotoxin and tryptase report on effector-cell activation in the acellular compartment.
• Soluble receptors and IgG4 — soluble FcεRII/CD23 and allergen-specific IgG4 are of particular interest as immunotherapy response markers, since IgG4 typically rises with successful desensitisation.
• Barrier and epithelial alarmins — periostin and related epithelial-derived proteins link airway and skin barrier dysfunction to systemic type 2 inflammation.
• Acellular by design — plasma is the correct input for immunoassay, multiplex and mass spectrometry workflows; cellular allergy assays such as basophil activation testing require a cellular product instead.

Donor Stratification Available

• Allergen class — food, aeroallergen/environmental, drug, venom, and latex sensitisation
• Clinical phenotype — allergic rhinitis, allergic asthma, atopic dermatitis, food allergy, and donors with a history of anaphylaxis
• Sensitisation profile — specific IgE-positive donors by allergen, and mono- versus poly-sensitised donors
• Serological severity — total IgE range and eosinophil-associated marker levels reported per lot where captured
• Treatment status — treatment-naive, on antihistamine or corticosteroid therapy, on allergen immunotherapy, or on type 2 biologic therapy
• Matched healthy non-atopic controls available, drawn on the same protocol and matched for age, sex and ethnicity

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed allergy donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request
• Volumes and anticoagulant options reported per lot

De-identified Donor Data

• Verified allergy diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Allergen sensitisation and treatment context reported per lot where captured
• Additional allergy-specific metadata available on request

Applications

• Total and allergen-specific IgE immunoassay development and validation
• Component-resolved diagnostic panel design and specificity testing
• Allergen-specific IgG4 and immunotherapy response marker studies
• Type 2 cytokine and soluble receptor quantification for biologic programmes
• Eosinophil and mast cell mediator profiling including tryptase and ECP
• Plasma proteomic and metabolomic discovery in atopic disease
• Diagnostic reference, calibrator and control material sourcing for allergy panels
• Therapeutic pharmacodynamic and target engagement readout development

Other Allergy Specimen Types

• Allergy Serum
• Allergy Bulk Plasma
• Allergy PBMC
• Allergy Leukopak
• Peanut Allergy Plasma

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Allergy plasma is available in standard and custom volumes. For pricing, international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare collection formats or check wider availability, visit our human plasma page.